CAUSES OF EARLY AGE RELATED MACULAR DEGENERATION

P2X7 IS AN ARCHAIC SCAVENGER RECEPTOR RECOGNIZING APOPTOTIC NEUROBLASTS IN EARLY HUMAN NEUROGENESIS

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

2021-03-17

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

Contribution of microglia and monocytes to the development and progression of age related macular degeneration

Erica L Fletcher

2020-02-04

PURPOSE: Age related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised nations. Based ..

Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

2019-08-01

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis

Hannah C Leeson, Maria A Kasherman, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Kelly M Toppinen, Ben J Gu, Michael W Weible

2018-11-01

Identifying the signaling mechanisms that regulate adult neurogenesis is essential to understanding how the brain may respond to n..

The Role of the Microglial Cx3crl Pathway in the Postnatal Maturation of Retinal Photoreceptors

Andrew I Jobling, Michelle Waugh, Kirstan A Vessey, Joanna A Phipps, Lidia Trogrlic, Una Greferath, Samuel A Mills, Zhi L Tan, Michelle M Ward, Erica L Fletcher

2018-05-16

Microglia are the resident immune cells of the CNS, and their response to infection, injury and disease is well documented. More r..

Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration

Kirstan A Vessey, Ben J Gu, Andrew I Jobling, Joanna A Phipps, Ursula Greferath, Mai X Tran, Michael A Dixon, Paul N Baird, Robyn H Guymer, James S Wiley, Erica L Fletcher

2017-08-01

Age-related macular degeneration (AMD) is a leading cause of irreversible, severe vision loss in Western countries. Recently, we i..

Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

A Dessa Sadovnick, Ben J Gu, Anthony L Traboulsee, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Maria G Criscuoli, Xin Huang, Amber Ou, Carol J Milligan, Steven Petrou, James S Wiley, Carles Vilarino-Guell

2017-06-01

Genetic variants in the purinergic receptors P2RX4 and P2RX7 have been shown to affect susceptibility to multiple sclerosis (MS). ..

Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration

Felix P Aplin, Erica L Fletcher, Chi D Luu, Kirstan A Vessey, Penelope J Allen, Robyn H Guymer, Robert K Shepherd, Mohit N Shivdasani

2016-10-01

Purpose: Retinal prostheses have emerged as a promising technology to restore vision in patients with severe photoreceptor degener..

X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age

Alexandra Grubman, Philipp Guennel, Kirstan A Vessey, Michael WM Jones, Simon A James, Martin D de Jonge, Anthony R White, Erica L Fletcher

2016-10-01

The biologically important metals such as zinc, copper and iron play key roles in retinal function, yet no study has mapped the sp..

Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease

Ben J Gu, Xin Huang, Amber Ou, Alan Rembach, Christopher Fowler, Pavan K Avula, Adam Horton, James D Doecke, Victor L Villemagne, S Lance Macaulay, Paul Maruff, Erica L Fletcher, Robyn Guymer, James S Wiley, Colin L Masters

2016-09-01

Sporadic Alzheimer's disease (AD) is characterised by the deposition and accumulation of specific protein aggregates. Failure of c..

Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen

Ursula Greferath, Robyn H Guymer, Kirstan A Vessey, Kate Brassington, Erica L Fletcher

2016-06-01

PURPOSE: To determine the histologic and cellular correlates in the retina and retinal pigment epithelium (RPE) with the presence ..

Retinal Changes in an ATP-Induced Model of Retinal Degeneration

Felix P Aplin, Kirstan A Vessey, Chi D Luu, Robyn H Guymer, Robert K Shepherd, Erica L Fletcher

2016-04-29

In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death p..

Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain

Tracy Ho, Andrew I Jobling, Ursula Greferath, Trinette Chuang, Archana Ramesh, Erica L Fletcher, Kirstan A Vessey

2015-10-06

Vesicular nucleotide transporter (VNUT) is required for active accumulation of adenosine tri-phosphate (ATP) into vesicles for pur..

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri

2015-10-01

Multiple sclerosis (MS) is a chronic relapsing-remitting inflammatory disease of the central nervous system characterized by oligo..

Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage

AI Jobling, RH Guymer, KA Vessey, U Greferath, SA Mills, KH Brassington, CD Luu, KZ Aung, L Trogrlic, M Plunkett, EL Fletcher

2015-02-01

Age-related macular degeneration (AMD) is a leading cause of vision loss, characterized by drusen deposits and thickened Bruch's m..

P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts

Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Ling

2015-02-01

During early human neurogenesis there is overproduction of neuroblasts and neurons accompanied by widespread programmed cell death..

IMMUNOLOCALIZATION OF THE P2X4 RECEPTOR ON NEURONS AND GLIA IN THE MAMMALIAN RETINA

T Ho, KA Vessey, EL Fletcher

2014-09-26

Extracellular adenosine 5'-triphosphate (eATP) acts as a neurotransmitter within the retina and brain, activating a range of ionot..