Causes Of Early Age Related Macular Degeneration

Grant number: 1061419 | Funding period: 2014 - 2017

Completed

Abstract

Age Related Macular degeneration (AMD) is a leading cause of blindess. In this project we will examine a possible cause for the development and progression of early AMD. In particular we will determine whether signaling of immune cells via receptors called purinergic receptors influences the removal of cellular debris as we age, predisposing people to the disease.

Related publications (6)

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P2X7 IS AN ARCHAIC SCAVENGER RECEPTOR RECOGNIZING APOPTOTIC NEUROBLASTS IN EARLY HUMAN NEUROGENESIS

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Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration

Felix P Aplin, Erica L Fletcher, Chi D Luu, Kirstan A Vessey, Penelope J Allen, Robyn H Guymer, Robert K Shepherd, Mohit N Shivdasani

2016-10-01

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Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain

Tracy Ho, Andrew I Jobling, Ursula Greferath, Trinette Chuang, Archana Ramesh, Erica L Fletcher, Kirstan A Vessey

2015-10-06

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A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri

2015-10-01

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Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage

AI Jobling, RH Guymer, KA Vessey, U Greferath, SA Mills, KH Brassington, CD Luu, KZ Aung, L Trogrlic, M Plunkett, EL Fletcher

2015-02-01

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P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts

Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Ling

2015-02-01