CAUSES OF EARLY AGE RELATED MACULAR DEGENERATION
Grant number: 1061419 | Funding period: 2014 - 2017
Age Related Macular degeneration (AMD) is a leading cause of blindess. In this project we will examine a possible cause for the development and progression of early AMD. In particular we will determine whether signaling of immune cells via receptors called purinergic receptors influences the removal of cellular debris as we age, predisposing people to the disease.
Related publications (18)
Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease
Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher
Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..
Targeting P2X7 receptors as a means for treating retinal disease
Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey
Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..
P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis
Hannah C Leeson, Maria A Kasherman, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Kelly M Toppinen, Ben J Gu, Michael W Weible
Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration
Kirstan A Vessey, Ben J Gu, Andrew I Jobling, Joanna A Phipps, Ursula Greferath, Mai X Tran, Michael A Dixon, Paul N Baird, Robyn H Guymer, James S Wiley, Erica L Fletcher
Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease
Ben J Gu, Xin Huang, Amber Ou, Alan Rembach, Christopher Fowler, Pavan K Avula, Adam Horton, James D Doecke, Victor L Villemagne, S Lance Macaulay, Paul Maruff, Erica L Fletcher, Robyn Guymer, James S Wiley, Colin L Masters
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri