CAUSES OF EARLY AGE RELATED MACULAR DEGENERATION

Grant number: 1061419 | Funding period: 2014 - 2017

Completed

Abstract

Age Related Macular degeneration (AMD) is a leading cause of blindess. In this project we will examine a possible cause for the development and progression of early AMD. In particular we will determine whether signaling of immune cells via receptors called purinergic receptors influences the removal of cellular debris as we age, predisposing people to the disease.

Related publications (18)

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P2X7 IS AN ARCHAIC SCAVENGER RECEPTOR RECOGNIZING APOPTOTIC NEUROBLASTS IN EARLY HUMAN NEUROGENESIS

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Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

2021-03-17

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

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Contribution of microglia and monocytes to the development and progression of age related macular degeneration

Erica L Fletcher

2020-02-04

PURPOSE: Age related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised nations. Based ..

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Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

2019-08-01

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

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P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis

Hannah C Leeson, Maria A Kasherman, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Kelly M Toppinen, Ben J Gu, Michael W Weible

2018-11-01

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The Role of the Microglial Cx3crl Pathway in the Postnatal Maturation of Retinal Photoreceptors

Andrew I Jobling, Michelle Waugh, Kirstan A Vessey, Joanna A Phipps, Lidia Trogrlic, Una Greferath, Samuel A Mills, Zhi L Tan, Michelle M Ward, Erica L Fletcher

2018-05-16

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Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration

Kirstan A Vessey, Ben J Gu, Andrew I Jobling, Joanna A Phipps, Ursula Greferath, Mai X Tran, Michael A Dixon, Paul N Baird, Robyn H Guymer, James S Wiley, Erica L Fletcher

2017-08-01

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Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

A Dessa Sadovnick, Ben J Gu, Anthony L Traboulsee, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Maria G Criscuoli, Xin Huang, Amber Ou, Carol J Milligan, Steven Petrou, James S Wiley, Carles Vilarino-Guell

2017-06-01

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Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration

Felix P Aplin, Erica L Fletcher, Chi D Luu, Kirstan A Vessey, Penelope J Allen, Robyn H Guymer, Robert K Shepherd, Mohit N Shivdasani

2016-10-01

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X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age

Alexandra Grubman, Philipp Guennel, Kirstan A Vessey, Michael WM Jones, Simon A James, Martin D de Jonge, Anthony R White, Erica L Fletcher

2016-10-01

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Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease

Ben J Gu, Xin Huang, Amber Ou, Alan Rembach, Christopher Fowler, Pavan K Avula, Adam Horton, James D Doecke, Victor L Villemagne, S Lance Macaulay, Paul Maruff, Erica L Fletcher, Robyn Guymer, James S Wiley, Colin L Masters

2016-09-01

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Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen

Ursula Greferath, Robyn H Guymer, Kirstan A Vessey, Kate Brassington, Erica L Fletcher

2016-06-01

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Retinal Changes in an ATP-Induced Model of Retinal Degeneration

Felix P Aplin, Kirstan A Vessey, Chi D Luu, Robyn H Guymer, Robert K Shepherd, Erica L Fletcher

2016-04-29

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Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain

Tracy Ho, Andrew I Jobling, Ursula Greferath, Trinette Chuang, Archana Ramesh, Erica L Fletcher, Kirstan A Vessey

2015-10-06

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A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri

2015-10-01

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Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage

AI Jobling, RH Guymer, KA Vessey, U Greferath, SA Mills, KH Brassington, CD Luu, KZ Aung, L Trogrlic, M Plunkett, EL Fletcher

2015-02-01

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P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts

Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Ling

2015-02-01

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IMMUNOLOCALIZATION OF THE P2X4 RECEPTOR ON NEURONS AND GLIA IN THE MAMMALIAN RETINA

T Ho, KA Vessey, EL Fletcher

2014-09-26