Ifitm3 - Making Cells Resistant to Virus Infection

Grant number: 1059051 | Funding period: 2014 - 2017

Completed

Abstract

In response to an infection cells within the body are capable of expressing a range of molecules that help them resist infection, one such molecule is interferon induced transmembrane protein 3 (IFITM3). This recently identified but poorly studied potent antiviral protein dramatically influences the course of influenza infection in both mice and humans. We will explore the mechanisms of antiviral activity of IFITM3 and determine factors important in initiating and retaining expression.

Related publications (3)

Endogenous murine BST-2/tetherin is not a major restriction factor of influenza a virus infection

SL Londrigan, MD Tate, ER Job, JM Moffat, LM Wakim, CA Gonelli, DFJ Purcell, AG Brooks, JA Villadangos, PC Reading, JD Mintern

2015-11-01

BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..

Respiratory DC use IFITM3 to avoid direct viral infection and safeguard virus-specific CD8 T cell priming

G Infusini, JM Smith, H Yuan, A Pizzolla, WC Ng, SL Londrigan, A Haque, PC Reading, JA Villadangos, LM Wakim

2015-11-01

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

2015-09-19

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..

University of Melbourne Researchers

Linda Wakim