ANTIPSYCHOTIC MEDICATION IN FIRST-EPISODE PSYCHOSIS: AN RCT TO ASSESS THE RISK-BENEFIT RATIO
Grant number: 1064704 | Funding period: 2014 - 2018
There has been an increasing emphasis on intervening early in psychotic disorders. A fundamental principle in early intervention is “to do no harm” and benefits must outweigh the risks of treatment. While antipsychotic medication is very effective and evidence-based form of treatment for positive symptoms in most first episode psychosis (FEP) patients it has risks. This study has the potential to determine whether antipsychotic medication should be the initial treatment option for FEP.
Related publications (6)
Longitudinal Illness- and Medication-Related Brain Volume Changes in Psychosis are Shaped by Connectome Architecture
Sidhant Chopra, Stuart Oldham, Alex Holmes, Ashlea Segal, Edwina Orchard, Kristina Sabaroedin, Shona Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Jeggan Tiego, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Suzy Harrigan, Christos Pantelis, Stephen Wood, Mark Bellgrove
Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression A Secondary Analysis of a Randomized Clinical Trial
Sidhant Chopra, Shona M Francey, Brian O'Donoghue, Kristina Sabaroedin, Aurina Arnatkeviciute, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Christos Pantelis, Stephen J Wood, Patrick McGorry, Alex Fornito
IMPORTANCE: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fM..
Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study
Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..
Cognitive ability and metabolic physical health in first-episode psychosis
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
Psychosocial Intervention With or Without Antipsychotic Medication for First-Episode Psychosis: A Randomized Noninferiority Clinical Trial
Shona M Francey, Brian O’Donoghue, Barnaby Nelson, Jessica Graham, Lara Baldwin, Hok Pan Yuen, Melissa J Kerr, Aswin Ratheesh, Kelly Allott, Mario Alvarez-Jimenez, Alex Fornito, Susy Harrigan, Andrew D Thompson, Stephen Wood, Michael Berk, Patrick D McGorry
<jats:title>Abstract</jats:title> <jats:p>This triple-blind (participants, clinicians, and researchers) randomized ..
Staged treatment and acceptability guidelines in early psychosis study (STAGES): A randomized placebo controlled trial of intensive psychosocial treatment plus or minus antipsychotic medication for first-episode psychosis with low-risk of self-harm or aggression. Study protocol and baseline characteristics of participants
Brian O'Donoghue, Shona M Francey, Barnaby Nelson, Aswin Ratheesh, Kelly Allott, Jessica Grahann, Lara Baldwin, Mario Alvarez-Jinnenez, Andrew Thonnpson, Alex Fornito, Andrea Polari, Michael Berk, Craig Macneil, Kingsley Crisp, Christos Pantelis, Hok P Yuen, Susy Harrigan, Patrick McGorry
AIM: It is now necessary to investigate whether recovery in psychosis is possible without the use of antipsychotic medication. Thi..