UNDERSTANDING THE MECHANISMS THAT REGULATE INFECTION-INDUCED PRETERM BIRTH
Grant number: 1058786 | Funding period: 2014 - 2016
Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of this project is to gain a better understanding of the mechanisms involved in premature birth with a view to future development of clinically useful interventions to reduce the high rates of mortality and long-term disability.
Related publications (19)
Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium.
R Lim, M Lappas
The pivotal role of inflammatory processes in human parturition is well known, but not completely understood. We have performed a ..
Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium
Identifying new targets that regulate myometrial activation are required to develop effective treatments to stop preterm labor. In..
The immunoproteasome inhibitor ONX-0914 regulates inflammation and expression of contraction associated proteins in myometrium
Stella Liong, Ratana Lim, Caitlyn Nguyen-Ngo, Gillian Barker, Helena C Parkington, Martha Lappas
There are currently no effective treatments to prevent spontaneous preterm labor. The precise upstream biochemical pathways that r..
DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leadin..
Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA
Stella Liong, Ratana Lim, Gillian Barker, Martha Lappas
PROBLEM: Intrauterine infection caused by viral infection has been implicated to contribute to preterm birth. Hepatitis A virus ce..
Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery
Ratana Lim, Gillian Barker, Martha Lappas
Spontaneous preterm birth remains the major cause of neonatal death and morbidity. Studies in non-gestational tissues report that ..
The Adaptor Protein p62 Mediates Nuclear Factor B Activation in Response to Inflammation and Facilitates the Formation of Prolabor Mediators in Human Myometrium
Preventing spontaneous preterm birth is one of the most important issues facing perinatal medicine today. The pathophysiology of p..
A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery
Ratana Lim, Gillian Barker, Ramkumar Menon, Martha Lappas
Preterm birth remains the major cause of neonatal mortality and morbidity, mediated largely by an inflammatory process. The sirtui..
ATF3 is a negative regulator of inflammation in human fetal membranes
Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas
INTRODUCTION: Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9..