NEW TREATMENTS FOR TRAUMATIC BRAIN INJURY
Grant number: 1061587 | Funding period: 2014 - 2016
Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.
Related publications (5)
The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of A beta burden through induction of APP amyloidogenic processing
Andrew Tsatsanis, Andrew N McCorkindale, Bruce X Wong, Ellis Patrick, Tim M Ryan, Robert W Evans, Ashley I Bush, Greg T Sutherland, Asipu Sivaprasadarao, Boris Guennewig, James A Duce
Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extrac..
Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention
Andrew Tsatsanis, Bruce X Wong, Adam P Gunn, Scott Ayton, Ashley I Bush, David Devos, James A Duce
The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..
Post Translational Modulation of -Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis
Andrew Tsatsanis, Stuart Dickens, Jessica CF Kwok, Bruce X Wong, James A Duce
Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron..
Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects
Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce
Ferroxidase activity has been reported to be altered in various biological fluids in neurodegenerative disease, but the sources co..
Bioavailable Trace Metals in Neurological Diseases
Aurelia Poujois, Jean-Christophe Devedjian, Caroline Moreau, David Devos, Pascal Chaine, France Woimant, James A Duce
OPINION STATEMENT: Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that hav..