NEW TREATMENTS FOR TRAUMATIC BRAIN INJURY

Grant number: 1061587 | Funding period: 2014 - 2016

Completed

Abstract

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.

Related publications (5)

University of Melbourne Researchers