NEW TREATMENTS FOR TRAUMATIC BRAIN INJURY

Grant number: 1061587 | Funding period: 2014 - 2016

Completed

Abstract

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.

Related publications (5)

Scholarly works icon

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of A beta burden through induction of APP amyloidogenic processing

Andrew Tsatsanis, Andrew N McCorkindale, Bruce X Wong, Ellis Patrick, Tim M Ryan, Robert W Evans, Ashley I Bush, Greg T Sutherland, Asipu Sivaprasadarao, Boris Guennewig, James A Duce

2021-08-16

Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extrac..

Scholarly works icon

Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention

Andrew Tsatsanis, Bruce X Wong, Adam P Gunn, Scott Ayton, Ashley I Bush, David Devos, James A Duce

2020-05-22

The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..

Scholarly works icon

Post Translational Modulation of -Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

Andrew Tsatsanis, Stuart Dickens, Jessica CF Kwok, Bruce X Wong, James A Duce

2019-06-01

Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron..

Scholarly works icon

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce

2017-04-01

Ferroxidase activity has been reported to be altered in various biological fluids in neurodegenerative disease, but the sources co..

Scholarly works icon

Bioavailable Trace Metals in Neurological Diseases

Aurelia Poujois, Jean-Christophe Devedjian, Caroline Moreau, David Devos, Pascal Chaine, France Woimant, James A Duce

2016-10-01

OPINION STATEMENT: Medical treatment in Wilson's disease includes chelators (D-penicillamine and trientine) or zinc salts that hav..

University of Melbourne Researchers