THE ROLE OF UBL-5 IN GLUCOSE METABOLISM

Grant number: 1069374 | Funding period: 2014 - 2016

Completed

Abstract

Type 2 diabetes is caused by insulin resistance, a condition that is characterised by the inability of insulin to elicit its normal function to lower blood sugar levels. The cause of insulin resistance is not known. In this study we will determine the role of a novel gene called UBL-5 to elicit insulin resistance in muscle and fat by generating genetically-induced models in which this gene has been deleted. By understanding the role of UBL-5 in insulin resistance, better therapeutic strategies can be developed to treat Type 2 diabetes.

University of Melbourne Researchers