STUDY OF THE ENZYMES THAT UNDERPIN THE GENETIC BLUEPRINT FOR MAINTAINING T CELL IMMUNITY.

Abstract

Recovery from infection, or vaccination, results in the establishment of protective immunity that persists for the life of an individual. Unfortunately, our understanding of how protective immunity is established and maintained after infection or vaccination is lacking. This proposal will determine whether specific enzymes involved in rewriting the genetic blueprint are key for establishing and maintaining this protective capacity. Understanding these mechanisms has implications for vaccination and improved immunotherapy strategies for cancer.