SMART DRUG DELIVERY USING NANOTECHNOLOGY TO PREVENT HEARING LOSS
Grant number: 1064375 | Funding period: 2014 - 2017
Hearing loss is a common sensory deficit and can get progressively worse over time, eventually requiring a cochlear implant. In this project we will examine the effectiveness of a new technique that uses nanoengineered particles to provide long term and controlled delivery of drugs in order to prevent progressive hearing loss and protect residual hearing following cochlear implantation. We will develop the next generation of nanotechnology to enhance drug delivery in pathological ears.
Related publications (18)
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery
Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..
Comparing perilymph proteomes across species.
Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green
OBJECTIVES/HYPOTHESIS: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding th..
Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea
Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd
Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells. Coinciding with hair cell degeneration, th..
Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study
Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon
OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature o..
Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea
Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd
Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..
Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea
Alexander C Thompson, James B Fallon, Andrew K Wise, Scott A Wade, Robert K Shepherd, Paul R Stoddart
At present there is some debate as to the processes by which infrared neural stimulation (INS) activates neurons in the cochlea, a..
Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso
Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..
Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso
This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..
DEVELOPMENT OF A CELL-BASED TREATMENT FOR LONG-TERM NEUROTROPHIN EXPRESSION AND SPIRAL GANGLION NEURON SURVIVAL
MP Zanin, M Hellstroem, RK Shepherd, AR Harvey, LN Gillespie
Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual degeneration following loss of the senso..
Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs
Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson
The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promo..