SMART DRUG DELIVERY USING NANOTECHNOLOGY TO PREVENT HEARING LOSS
Grant number: 1064375 | Funding period: 2014 - 2017
Hearing loss is a common sensory deficit and can get progressively worse over time, eventually requiring a cochlear implant. In this project we will examine the effectiveness of a new technique that uses nanoengineered particles to provide long term and controlled delivery of drugs in order to prevent progressive hearing loss and protect residual hearing following cochlear implantation. We will develop the next generation of nanotechnology to enhance drug delivery in pathological ears.
Related publications (16)
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
Comparing perilymph proteomes across species.
Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green
OBJECTIVES/HYPOTHESIS: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding th..
Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso
Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..