SMART DRUG DELIVERY USING NANOTECHNOLOGY TO PREVENT HEARING LOSS

Grant number: 1064375 | Funding period: 2014 - 2017

Completed

Abstract

Hearing loss is a common sensory deficit and can get progressively worse over time, eventually requiring a cochlear implant. In this project we will examine the effectiveness of a new technique that uses nanoengineered particles to provide long term and controlled delivery of drugs in order to prevent progressive hearing loss and protect residual hearing following cochlear implantation. We will develop the next generation of nanotechnology to enhance drug delivery in pathological ears.

Related publications (16)

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

2019-09-09

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

2018-09-19

Comparing perilymph proteomes across species.

Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green

2018-01-01

OBJECTIVES/HYPOTHESIS: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding th..

Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea

Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd

2017-12-01

Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study

Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon

2017-08-01

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

2016-10-27

Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea

Alexander C Thompson, James B Fallon, Andrew K Wise, Scott A Wade, Robert K Shepherd, Paul R Stoddart

2015-06-01

Treating hearing disorders with cell and gene therapy

Lisa N Gillespie, Rachael T Richardson, Bryony A Nayagam, Andrew K Wise

2014-12-01

Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).

Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso

2014-11-01

Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

2014-11-01

DEVELOPMENT OF A CELL-BASED TREATMENT FOR LONG-TERM NEUROTROPHIN EXPRESSION AND SPIRAL GANGLION NEURON SURVIVAL

MP Zanin, M Hellstroem, RK Shepherd, AR Harvey, LN Gillespie

2014-09-26

A partial hearing animal model for chronic electro-acoustic stimulation

S Irving, AK Wise, RE Millard, RK Shepherd, JB Fallon

2014-08-01

Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

2014-07-18

Gene Therapy Boosts the Bionic Ear

Robert K Shepherd, Andrew K Wise

2014-04-23

Viability of Long-Term Gene Therapy in the Cochlea

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

2014-04-22

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

2014-01-01

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