SMART DRUG DELIVERY USING NANOTECHNOLOGY TO PREVENT HEARING LOSS

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

2019-09-09

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

New molecular therapies for the treatment of hearing loss

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

2019-08-01

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Focused electrical simulation using a single current source

P Senn, RK Shepherd, JB Fallon

2018-10-01

OBJECTIVE: Cochlear implants, while providing significant benefits to recipients, remain limited due to broad neural activation. F..

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

2018-09-19

Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..

Comparing perilymph proteomes across species.

Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green

2018-01-01

OBJECTIVES/HYPOTHESIS: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding th..

Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea

Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd

2017-12-01

Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells. Coinciding with hair cell degeneration, th..

Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study

Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon

2017-08-01

OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature o..

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

2016-10-27

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..

Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea

Alexander C Thompson, James B Fallon, Andrew K Wise, Scott A Wade, Robert K Shepherd, Paul R Stoddart

2015-06-01

At present there is some debate as to the processes by which infrared neural stimulation (INS) activates neurons in the cochlea, a..

Treating hearing disorders with cell and gene therapy

Lisa N Gillespie, Rachael T Richardson, Bryony A Nayagam, Andrew K Wise

2014-12-01

Hearing loss is an increasing problem for a substantial number of people and, with an aging population, the incidence and severity..

Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).

Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso

2014-11-01

Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

2014-11-01

This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..

DEVELOPMENT OF A CELL-BASED TREATMENT FOR LONG-TERM NEUROTROPHIN EXPRESSION AND SPIRAL GANGLION NEURON SURVIVAL

MP Zanin, M Hellstroem, RK Shepherd, AR Harvey, LN Gillespie

2014-09-26

Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual degeneration following loss of the senso..

A partial hearing animal model for chronic electro-acoustic stimulation

S Irving, AK Wise, RE Millard, RK Shepherd, JB Fallon

2014-08-01

OBJECTIVE: Cochlear implants (CIs) have provided some auditory function to hundreds of thousands of people around the world. Altho..

Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

2014-07-18

The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promo..

Gene Therapy Boosts the Bionic Ear

Robert K Shepherd, Andrew K Wise

2014-04-23

Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear (Pinyon et al., this ..

Viability of Long-Term Gene Therapy in the Cochlea

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

2014-04-22

Gene therapy has been investigated as a way to introduce a variety of genes to treat neurological disorders. An important clinical..

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

2014-01-01

Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force ..