STRESS AND ENVIRONMENT MODULATING MESIAL TEMPORAL LOBE EPILEPSY
Grant number: 1059860 | Funding period: 2014 - 2016
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
Related publications (7)
Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice
Nigel C Jones, Matthew Hudson, Joshua Foreman, Gil Rind, Rachel Hill, Elizabeth E Manning, Maarten van den Buuse
Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Defici..
Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors
Crystal Li, Juliana Silva, Ezgi Ozturk, Gabriella Dezsi, Terence J O'Brien, Thibault Renoir, Nigel C Jones
Patients with epilepsy often have mood disorders, and these are commonly treated with antidepressant drugs. Although these drugs a..
Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model
Kim L Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg von Jonquieres, Terence J O'Brien, Margaret J Morris
Neuropeptide Y (NPY) is an important 36 amino acid peptide that is abundantly expressed in the mammalian CNS and is known to be an..
Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety
Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones
INTRODUCTION: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on..
Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine
MR Hudson, G Rind, TJ O'Brien, NC Jones
Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely ti..
Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity
Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones
OBJECTIVE: Environmental exposures impart powerful effects on vulnerability to many brain diseases, including epilepsy. Mesial tem..
The challenge and promise of anti-epileptic therapy development in animal models
Michele Simonato, Amy R Brooks-Kayal, Jerome Engel, Aristea S Galanopoulou, Frances E Jensen, Solomon L Moshe, Terence J O'Brien, Asia Pitkanen, Karen S Wilcox, Jacqueline A French
Translation of successful target and compound validation studies into clinically effective therapies is a major challenge, with po..