IMPROVING THE PREDICTION AND DETECTION OF CONTRIBUTORS TO TERM STILLBIRTH

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Damanpreet Garcha, Susan P Walker, Teresa M MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E Illanes, Jhy K Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J Hannan

2021-08-16

Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomar..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

2021-02-01

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight.

Lucy M Kennedy, Stephen Tong, Alice J Robinson, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald

2020-12-24

BACKGROUND: Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-g..

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Richard Hiscock, Natalie J Hannan, Natasha Pritchard, Ping Cannon, Vi Nguyen Tuong, Manisha Miranda, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2020-10-22

Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ inj..

Appropriate-for-gestational-age infants who exhibit reduced antenatal growth velocity display postnatal catch-up growth

Emma J McLaughlin, Richard J Hiscock, Alice J Robinson, Lisa Hui, Stephen Tong, Kirsten M Dane, Anna L Middleton, Susan P Walker, Teresa M MacDonald

2020-09-08

BACKGROUND: Postnatally, small-for-gestational-age (SGA; birthweight <10th centile) infants who are growth restricted due to utero..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

2020-05-15

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-relate..

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin

Teresa M MacDonald, Susan P Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2020-02-01

INTRODUCTION: Recently, Delta-like homolog 1 (DLK1) was identified as a potential marker of small-for-gestational-age (SGA; <10th ..

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

2019-12-01

INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. ..

Screening circulating proteins to identify biomarkers of fetal macrosomia.

Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald

2019-09-18

OBJECTIVE: Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal ..

Blood-based biomarkers in the maternal circulation associated with fetal growth restriction

Stephen Tong, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Teresa Mary MacDonald

2019-07-22

Fetal growth restriction (FGR) is associated with threefold to fourfold increased risk of stillbirth. Identifying FGR, through its..

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

2019-04-01

Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothe..

Prospective longitudinal assessment of the fetal left modified Myocardial Performance Index

Teresa M MacDonald, Alice J Robinson, Susan P Walker, Lisa Hui

2019-03-04

INTRODUCTION: The fetal left modified Myocardial Performance Index (Mod-myocardial performance index (MPI)) is a measure of systol..

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Vi Nguyen Tuong, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2019-01-18

Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothe..

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Teresa M MacDonald, Tran Chuong, Tu'uhevaha J Kaitu'u-Lino, Shaun P Brennecke, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Ping Cannon, Susan P Walker, Stephen Tong

2018-08-31

BACKGROUND: Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. ..

Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

Teresa M MacDonald, Lisa Hui, Stephen Tong, Alice J Robinson, Kirsten M Dane, Anna L Middleton, Susan P Walker

2017-08-31

BACKGROUND: While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of sti..

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation

Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

2016-04-01

BACKGROUND: Late-onset fetal growth restriction (FGR) is often undetected prior to birth, which puts the fetus at increased risk o..

Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study

Nadia Bardien, Clare L Whitehead, Stephen Tong, Antony Ugoni, Susan McDonald, Susan P Walker

2016-01-05

OBJECTIVES: To determine whether fetuses that slow in growth but are then born appropriate for gestational age (AGA, birthweight >..