CHARACTERISATION OF PRE-MALIGNANT BREAST LESIONS
Grant number: 1063092 | Funding period: 2014 - 2017
Understanding the full repertoire of genetic events that underlie the development of breast cancer may allow development of prevention strategies. This study will analyse genetic data of benign breast lesions that may be non-obligate precursors of breast cancer. Importantly, clinical management of these lesions is difficult. A reliable method of predicting the risk of progression to cancer would be a significant advance, with benefits to individual patients and also the health system.
Related publications (5)
The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma
Tanjina Kader, Kenneth Elder, Magnus Zethoven, Timothy Semple, Prue Hill, David L Goode, Niko Thio, Dane Cheasley, Simone M Rowley, David J Byrne, Jia-Min Pang, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe
Intraductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The mole..
Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma
Tanjina Kader, Prue Hill, Magnus Zethoven, David L Goode, Kenneth Elder, Niko Thio, Maria Doyle, Timothy Semple, Wajiha Sufyan, David J Byrne, Jia-Min B Pang, Anand Murugasu, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe
The current model for breast cancer progression proposes independent 'low grade (LG)-like' and 'high grade (HG)-like' pathways but..
Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape
Tanjina Kader, Prue Hill, Emad A Rakha, Ian G Campbell, Kylie L Gorringe
BACKGROUND: Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem wit..
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer
Jia-Min B Pang, Peter Savas, Andrew P Fellowes, Gisela Mir Arnau, Tanjina Kader, Ravikiran Vedururu, Chelsee Hewitt, Elena A Takano, David J Byrne, David YH hoong, Ewan KA Millar, C Soon Lee, Sandra A O'Toole, Sunil R Lakhani, Margaret C Cummings, G Bruce Mann, Ian G Campbell, Alexander Dobrovic, Sherene Loi, Kylie L Gorringe
The spectrum of genomic alterations in ductal carcinoma in situ (DCIS) is relatively unexplored, but is likely to provide useful i..
Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue
Tanjina Kader, David L Goode, Stephen Q Wong, Jacquie Connaughton, Simone M Rowley, Lisa Devereux, David Byrne, Stephen B Fox, Gisela Mir Arnau, Richard W Tothill, Ian G Campbell, Kylie L Gorringe
Unlocking clinically translatable genomic information, including copy number alterations (CNA), from formalin-fixed paraffin-embed..