NEUROINFLAMMATION IN SCHIZOPHRENIA
Grant number: 1065742 | Funding period: 2014 - 2017
This project will investigate whether brain inflammation contributes to progressive brain volume loss in people with schizophrenia. Using novel brain scanning we will index whether brain cells involved in inflammation, called microglia, are in an activated state in people with schizophrenia. We expect microglia will be ‘activated’ in a subgroup of patients with schizophrenia, and will be related to progressive brain volume loss in these patients. This information will help us develop new treatments to prevent brain volume loss in the illness.
Related publications (6)
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors
Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky
In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..
Investigation of peripheral complement factors across stages of psychosis
Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley
The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..
Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz
INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..
White matter connectivity disruptions in early and chronic schizophrenia
MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky
BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley
We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..
Microglial activation and progressive brain changes in schizophrenia
LE Laskaris, MA Di Biase, I Everall, G Chana, A Christopoulos, E Skafidas, VL Cropley, C Pantelis
Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, de..