A NOVEL APPROACH TO RESTORATION OF TUMOUR SUPPRESSION IN LUNG CANCER

E6AP promotes prostate cancer by reducing p27 expression

Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt

2017-06-27

Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously ..

The role of MDM2 and MDM4 in breast cancer development and prevention

Sue Haupt, Reshma Vijayakumaran, Panimaya Jeffreena Miranda, Andrew Burgess, Elgene Lim, Ygal Haupt

2017-02-01

The major cause of death from breast cancer is not the primary tumour, but relapsing, drug-resistant, metastatic disease. Identify..

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt

2017-01-10

The tumor suppressor p16INK4a, one protein encoded by the INK4/ARF locus, is frequently absent in multiple cancers, including non-..

Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

C Gamell, T Gulati, B Solomon, S Haupt, Y Haupt

2017-01-01

A key step during onset of most cases of non-small cell lung cancer (NSCLC) is the loss of the tumor suppressor p16INK4a (best kno..

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

2016-12-01

Restoration of tumor suppression is an attractive onco-therapeutic approach. It is particularly relevant when a tumor suppressor i..

Editorial: Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

Ygal Haupt, Giovanni Blandino

2016-07-12

Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways

Sue Haupt, Dinesh Raghu, Ygal Haupt

2016-01-27

The tumor suppressor p53 normally acts as a brake to halt damaged cells from perpetrating their genetic errors into future generat..

Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, J-MB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, T-M Rogers, AFAS Teunisse, MJ Herold, J-C Marine, SB Fox, A Jochemsen, Y Haupt

2015-07-01

The function of the tumor suppressor p53 is universally compromised in cancers. It is the most frequently mutated gene in human ca..

p53 calls upon CIA (Calcium Induced Apoptosis) to counter stress

Sue Haupt, Dinesh Raghu, Ygal Haupt

2015-03-10

PML tumour suppression and beyond: Therapeutic implications

Cristina Gamell, Piotr Jan Paul, Ygal Haupt, Sue Haupt

2014-08-19

Recognition of the tumour suppressive capacity of the Promyelocytic Leukemia protein (PML) has emerged beyond its identification t..

The p53-Mdm2 loop: a critical juncture of stress response.

Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt

2014-01-01

The presence of a functional p53 protein is a key factor for the proper suppression of cancer development. A loss of p53 activity,..