A Novel Approach to Restoration of Tumour Suppression in Lung Cancer

Grant number: 1063389 | Funding period: 2014 - 2016

Completed

Abstract

Loss of a tumour suppressor is a key event in every cancer, including lung cancer. Therefore restoration of the expression and/or activity of the tumour suppressor is an attractive approach to anti-cancer treatment. In order to restore tumour suppression, a detailed understanding of the mechanism by which a given tumour suppressor is regulated is required. This application focuses on our discovery of a novel mechanism by which a key tumour suppressor of lung cancer is regulated.

Related publications (5)

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Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

C Gamell, T Gulati, B Solomon, S Haupt, Y Haupt

2017-09-03

A key step during onset of most cases of non-small cell lung cancer (NSCLC) is the loss of the tumor suppressor p16<sup>INK4a</sup..

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Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

C Gamell, T Gulati, Y Levav-Cohen, RJ Young, H Do, P Pilling, E Takano, N Watkins, SB Fox, P Russell, D Ginsberg, BJ Monahan, G Wright, A Dobrovic, S Haupt, B Solomon, Y Haupt

2017-01-10

The tumor suppressor p16<sup>INK4a</sup>, one protein encoded by the INK4/ARF locus, is frequently absent in multiple cancers, inc..

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E6AP promotes prostate cancer by reducing p27 expression

D Raghu, PJ Paul, T Gulati, S Deb, C Khoo, A Russo, E Gallo, G Blandino, AL Chan, E Takano, SK Sandhu, SB Fox, S Williams, S Haupt, C Gamell, Y Haupt

2017-01-01

Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously ..

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Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, AL Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

2016-12-01

Restoration of tumor suppression is an attractive onco-therapeutic approach. It is particularly relevant when a tumor suppressor i..

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Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, JMB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, TM Rogers, AFAS Teunisse, MJ Herold, JC Marine, SB Fox, A Jochemsen, Y Haupt

2015-07-01

The function of the tumor suppressor p53 is universally compromised in cancers. It is the most frequently mutated gene in human ca..

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