The Tlr2 Agonist Pam2cys As An Antimicrobial Agent

Abstract

Lower respiratory infections are the leading infectious cause of death worldwide. We have discovered a compound that reduces the impact and disease caused by viral and bacterial infections. This study will develop the prophylactic capabilities of this agent against transmission of influenza virus A and development of secondary bacterial disease. In addition, we will identify the mechanism of action for this compound, and its utility as a broad-spectrum intervention measure against viral and bacterial infections.

Related publications (1)

Generation of adaptive immune responses following influenza virus challenge is not compromised by pre-treatment with the TLR-2 agonist Pam(2)Cys

Edin Jessica Mifsud, Amabel CL Tan, Lorena Elizabeth Brown, Brendon Yew Loong Chua, David C Jackson

2015-06-05