A NEW STRATEGY FOR TREATING DEMYELINATING DISEASES
Grant number: 1058647 | Funding period: 2014 - 2017
Incomplete remyelination is a significant component of the persistent clinical disability of peripheral demyelinating neuropathy, contributing to conduction deficits and the secondary axonal damage. A crucial therapeutic challenge is to identify ways to promote remyelination. This project aims to develop a new strategy and a novel clinically relevant target for treating peripheral demyelinating neuropathy.
Related publications (8)
The dynamics of oligodendrocyte generation: how distinct is the mouse from the human?
David G Gonsalvez, Georgina A Craig, Darragh M Walsh, Barry D Hughes, Rhiannon J Wood, Sang Won Yoo, Simon S Murray, Junhua Xiao
<jats:p>Murine oligodendrocyte generation dynamics are considered distinct from those in the human, with implications for cross-sp..
Partial deletion of p75(NTR)in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neuronsin vivo
Zuoheng Qin, David G Gonsalvez, Rhiannon J Wood, Fatemeh Daemi, Sangwon Yoo, Jason J Ivanusic, Elizabeth J Coulson, Simon S Murray, Junhua Xiao
The p75 neurotrophin receptor (p75NTR ) is required for maintaining peripheral sensory neuron survival and function; however, the ..
BDNF haploinsufficiency exerts a transient and regionally different influence upon oligodendroglial lineage cells during postnatal development
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, Maarten van den Buuse, Simon S Murray, Junhua Xiao
Brain-Derived Neurotrophic Factor (BDNF) plays important roles in promoting myelination in the developing central nervous system (..
Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain
Jessica Fletcher, Rhiannon Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan Northfield, Richard Hughes, David Gonsalvez, Junhua Xiao, Simon Murray
<h4>Methods: </h4> to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of c..
Myelin Protein Zero(180-199) Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice
David G Gonsalvez, SangWon Yoo, Georgina A Craig, Rhiannon J Wood, Jessica L Fletcher, Simon S Murray, Junhua Xiao
Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study of disease pathogenesis. Further,..
A Brain-Derived Neurotrophic Factor-Based p75(NTR) Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination
David G Gonsalvez, Giang Tran, Jessica L Fletcher, Richard A Hughes, Suzanne Hodgkinson, Rhiannon J Wood, Sang Won Yoo, Mithraka De Silva, Wong W Agnes, Catriona McLean, Paul Kennedy, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The n..
Fyn is an Intermediate Kinase that BDNF Utilizes to Promote Oligodendrocyte Myelination
Haley Peckham, Lauren Giuffrida, Rhiannon Wood, David Gonsalvez, Anita Ferner, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Fyn, a member of the Src family of nonreceptor tyrosine kinases, promotes central nervous system myelination during development; h..
TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination
Agnes W Wong, Lauren Giuffrida, Rhiannon Wood, Haley Peckham, David Gonsalvez, Simon S Murray, Richard A Hughes, Junhua Xiao
Brain-derived neurotrophic factor (BDNF) plays critical roles in the development and maintenance of the central (CNS) and peripher..