TRANSPLANTATION OF PIG ISLETS TO TREAT DIABETES

Grant number: 1061868 | Funding period: 2014 - 2018

Completed

Abstract

Type 1 diabetes destroys the body’s insulin-producing cells (islets), resulting in high blood sugar levels and the prospect of devastating complications. Replacement of islets by transplantation is the only way to restore normal blood sugar control, but (i) is limited by the shortage of human donors and (ii) carries risks associated with anti-rejection drugs. This project aims to solve both problems by using humanized pigs as donors combined with a novel approach to inducing tolerance to the transplanted islets.

Related publications (5)

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Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons

Wayne J Hawthorne, Evelyn J Salvaris, Yi Vee Chew, Heather Burns, Joanne Hawkes, Helen Barlow, Min Hu, Andrew M Lew, Mark B Nottle, Philip J O'Connell, Peter J Cowan

2022-06-16

Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an alternative therapy for treatment of ..

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FokI-dCas9 mediates high-fidelity genome editing in pigs

Nella Fisicaro, Evelyn J Salvaris, Gayle K Philip, Matthew J Wakefield, Mark B Nottle, Wayne J Hawthorne, Peter Cowan

2019-09-01

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GGTA1 knock-in pigs expressing the anti-CD2 monoclonal antibody diliximab from the porcine insulin promoter

Evelyn Salvaris, Nella Fisicaro, Stephen McIlfatrick, Ivan Vassiliev, Andrew M Lew, Wayne J Hawthorne, Mark B Nottle, Peter J Cowan

2019-09-01

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FokI-dCas9 mediates high-fidelity genome editing in pigs

Nella Fisicaro, Evelyn J Salvaris, Gayle K Philip, Matthew J Wakefield, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan

2019-08-12

Gene editing using clustered regularly interspaced short palindromic repeats/Cas9 has great potential for improving the compatibil..

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Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

Mark B Nottle, Evelyn J Salvaris, Nella Fisicaro, Stephen McIlfatrick, Ivan Vassiliev, Wayne J Hawthorne, Philip J O'Connell, Jamie L Brady, Andrew M Lew, Peter J Cowan

2017-08-16

Xenotransplantation from pigs has been advocated as a solution to the perennial shortage of donated human organs and tissues. CRIS..

University of Melbourne Researchers