Improving Pregnancy Outcomes for Women With Preeclampsia

Grant number: 1064845 | Funding period: 2014 - 2016

Completed

Abstract

This project will substantially improve our understanding of the potential causes of vascular complications of pregnancy including preeclampsia, and provide a solid foundation to develop new clinical interventions for women who develop this disease during their pregnancy. It will also investigate if a peptide hormone, relaxin, could be an effective treatment to manage the health of women diagnosed with preeclampsia during their pregnancy and prevent delivery of severely premature infants.

Related publications (3)

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.

Cheng Xue Qin, Jarryd Anthonisz, Chen Huei Leo, Nicola Kahlberg, Anida Velagic, Mandy Li, Edwina Jap, Owen L Woodman, Laura J Parry, John D Horowitz, Barbara K Kemp-Harper, Rebecca H Ritchie

2020-01-01

Aim: Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many c..

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)

SA Marshall, K O'Sullivan, HH Ng, RAD Bathgate, LJ Parry, MA Hossain, CH Leo

2017-01-01

Recombinant H2 relaxin (serelaxin) has gained considerable attention as a new vasoprotective drug, largely due to its potential th..

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

N Kahlberg, CX Qin, J Anthonisz, E Jap, HH Ng, M Jelinic, LJ Parry, BK Kemp-Harper, RH Ritchie, CH Leo

2016-09-01

Increased vascular stiffness and reduced endothelial nitric oxide ([Formula presented]) bioavailability are characteristic of diab..

University of Melbourne Researchers

Stephen Tong