IMPROVING PREGNANCY OUTCOMES FOR WOMEN WITH PREECLAMPSIA
Grant number: 1064845 | Funding period: 2014 - 2016
This project will substantially improve our understanding of the potential causes of vascular complications of pregnancy including preeclampsia, and provide a solid foundation to develop new clinical interventions for women who develop this disease during their pregnancy. It will also investigate if a peptide hormone, relaxin, could be an effective treatment to manage the health of women diagnosed with preeclampsia during their pregnancy and prevent delivery of severely premature infants.
Related publications (4)
Relaxin Deficiency Leads to Uterine Artery Dysfunction During Pregnancy in Mice
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function ..
B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)
Sarah A Marshall, Kelly O'Sullivan, Hooi Hooi Ng, Ross AD Bathgate, Laura J Parry, Mohammed Akhter Hossain, Chen Huei Leo
Recombinant H2 relaxin (serelaxin) has gained considerable attention as a new vasoprotective drug, largely due to its potential th..
Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries
Nicola Kahlberg, Cheng Xue Qin, Jarryd Anthonisz, Edwina Jap, Hooi Hooi Ng, Maria Jelinic, Laura J Parry, Barbara K Kemp-Harper, Rebecca H Ritchie, Chen Huei Leo
Increased vascular stiffness and reduced endothelial nitric oxide (NO) bioavailability are characteristic of diabetes. Whether the..
Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation
Sarah A Marshall, Leelee Ng, Elaine N Unemori, Jane E Girling, Laura J Parry
BACKGROUND: Extensive uterine adaptations, including angiogenesis, occur prior to implantation in early pregnancy and are potentia..