Investigating Secondary Effects of Bace1 Inhibition, a Promising Therapy for Alzheimer's Disease

The β-Secretase Substrate Seizure 6–Like Protein (SEZ6L) Controls Motor Functions in Mice

E Ong-Pålsson, JR Njavro, Y Wilson, M Pigoni, A Schmidt, SA Müller, M Meyer, J Hartmann, MA Busche, JM Gunnersen, KM Munro, SF Lichtenthaler

2022-02-01

The membrane protein seizure 6–like (SEZ6L) is a neuronal substrate of the Alzheimer’s disease protease BACE1, and little is known..

BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory

A Nash, HJM Gijsen, BJ Hrupka, KSL Teng, SF Lichtenthaler, H Takeshima, JM Gunnersen, KM Munro

2021-12-01

BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alz..

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

M Pigoni, HE Hsia, J Hartmann, J Rudan Njavro, MD Shmueli, SA Müller, G Güner, J Tüshaus, PH Kuhn, R Kumar, P Gao, ML Tran, B Ramazanov, B Blank, AL Hipgrave Ederveen, J Von Blume, C Mulle, JM Gunnersen, M Wuhrer, G Rammes

2020-08-03

Seizure protein 6 (SEZ6) is required for the development and maintenance of the nervous system, is a major substrate of the protea..

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

A Nash, TD Aumann, M Pigoni, SF Lichtenthaler, H Takeshima, KM Munro, JM Gunnersen

2020-04-14

Seizure-related gene 6 (Sez6), Sez6-Like (Sez6L), and Sez6-Like 2 (Sez6L2) comprise a family of homologous proteins widely express..

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

K Zhu, X Xiang, S Filser, P Marinković, MM Dorostkar, S Crux, U Neumann, DR Shimshek, G Rammes, C Haass, SF Lichtenthaler, JM Gunnersen, J Herms

2018-03-01

Background: Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheime..

Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System

KM Munro, A Nash, M Pigoni, SF Lichtenthaler, JM Gunnersen

2016-11-01

Inhibition of the protease β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a promising treatment strategy for Alzhei..

The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome

SS Li, Z Qu, M Haas, L Ngo, YJ Heo, HJ Kang, JM Britto, HD Cullen, HK Vanyai, SS Tan, T Chan-Ling, JM Gunnersen, JIT Heng

2016-07-11

Copy number variations to chromosome 21 (HSA21) cause intellectual disability and Down Syndrome, but our understanding of the HSA2..

Seizure-6 proteins highlight BACE1 functions in neurobiology

M Pigoni, J GUNNERSEN, SF Lichtenthaler

2016-01-01

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

M Pigoni, J Wanngren, PH Kuhn, KM Munro, JM Gunnersen, H Takeshima, R Feederle, I Voytyuk, B De Strooper, MD Levasseur, BJ Hrupka, SA Müller, SF Lichtenthaler

2016-01-01

Background: The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer's disease. However, BACE1 thera..

BACE Inhibition as a Therapeutic Strategy for Alzheimer’s Disease

G Evin, SJ Fuller, JM Gunnersen

2015-07-22

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease and the most common cause of dementia. One of th..

BACE Inhibition as a Therapeutic Strategy for Alzheimer`s Disease

Genevieve Evin, Stephanie J. Fuller, Jenny M. Gunnersen

2015-05-30