DEVELOPING DIAGNOSTICS AND THERAPEUTICS FOR PREECLAMPSIA: TARGETING A NOVEL PLACENTAL SPECIFIC SFLT-1 VARIANT

Grant number: 1061977 | Funding period: 2014 - 2016

Completed

Abstract

Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects of sFlt-1 as a strategy to develop drugs.