NEURAL CONTROL OF BEHAVIOURAL STATE AND COGNITION
Grant number: 1067522 | Funding period: 2014 - 2016
Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective therapies are required. Our research is using preclinical models to characterize a little studied neural network in the control of arousal states, rhythmic brain activity, and learning and memory. Our findings could advance the development of improved treatments for cognitive deficits in degenerative, age-related and psychiatric disorders.
Related publications (19)
RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior
Alan Kania, Agata Szlaga, Patryk Sambak, Anna Gugula, Ewa Blasiak, Maria Vittoria Micioni Di Bonaventura, Mohammad Akhter Hossain, Carlo Cifani, Grzegorz Hess, Andrew L Gundlach, Anna Blasiak
Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding ..
Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter
Alexander D Wykes, Sherie Ma, Ross AD Bathgate, Andrew L Gundlach
Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key ..
Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats
Camila de Avila, Sandrine Chometton, Sherie Ma, Lola Torz Pedersen, Elena Timofeeva, Carlo Cifani, Andrew L Gundlach
Eating disorders are frequently triggered by stress and are more prevalent in women than men. First signs often appear during earl..
Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance
Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach
Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Hector Albert-Gasco, Sandra Sanchez-Sarasua, Sherie Ma, Cristina Garcia-Diaz, Andrew L Gundlach, Ana M Sanchez-Perez, Francisco E Olucha-Bordonau
In mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygda..
Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior
Adam J Lawther, Andrew Flavell, Sherie Ma, Stephen Kent, Christopher A Lowry, Andrew L Gundlach, Matthew W Hale
Anxiety-related defensive behavior is controlled by a distributed network of brain regions and interconnected neural circuits. The..
Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding
Azadeh Sabetghadam, Agnieszka Grabowiecka-Nowak, Alan Kania, Anna Gugula, Ewa Blasiak, Tomasz Blasiak, Sherie Ma, Andrew L Gundlach, Anna Blasiak
The rat nucleus incertus (NI) contains GABA/peptide-projection neurons responsive to orexin (hypocretin)/orexin receptor-2 (OX2) s..
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Francisco E Olucha-Bordonau, Hector Albert-Gasco, Francisco Ros-Bernal, Valeria Rytova, Emma KE Ong-Palsson, Sherie Ma, Ana M Sanchez-Perez, Andrew L Gundlach
The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal fore..
Dual-transmitter systems regulating arousal, attention, learning and memory.
Sherie Ma, Balázs Hangya, Christopher S Leonard, William Wisden, Andrew L Gundlach
An array of neuromodulators, including monoamines and neuropeptides, regulate most behavioural and physiological traits. In the pa..
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Stanislaw Mitew, Ilan Gobius, Laura R Fenlon, Stuart J McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L Gundlach, Linda J Richards, Trevor J Kilpatrick, Tobias D Merson, Ben Emery
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of..
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
Hector Albert-Gasco, Sherie Ma, Francisco Ros-Bernal, Ana M Sanchez-Perez, Andrew L Gundlach, Francisco E Olucha-Bordonau
The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and cont..
Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats
Camila de Avila, Sandrine Chometton, Christophe Lenglos, Juliane Calvez, Andrew L Gundlach, Elena Timofeeva
The neuropeptide relaxin-3 (RLN3) binds with high affinity to its cognate receptor, relaxin-family peptide receptor 3 (RXFP3), and..
Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory
M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
Hippocampus is innervated by γ-aminobutyric acid (GABA) "projection" neurons of the nucleus incertus (NI), including a population ..
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe
Relaxin-3 has been proposed to modulate emotional-behavioural functions such as arousal and behavioural activation, appetite regul..
Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control
Anna Blasiak, Andrew L Gundlach, Grzegorz Hess, Marian H Lewandowski
Many physiological processes fluctuate throughout the day/night and daily fluctuations are observed in brain and peripheral levels..
Nucleus incertus promotes cortical desynchronization and behavioral arousal
Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach
Arousal and vigilance are essential for survival and relevant regulatory neural circuits lie within the brainstem, hypothalamus an..
Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
Fabio N Santos, Celia W Pereira, Ana M Sanchez-Perez, Marcos Otero-Garcia, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau
The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerfu..
ANXIOGENIC DRUG ADMINISTRATION AND ELEVATED PLUS-MAZE EXPOSURE IN RATS ACTIVATE POPULATIONS OF RELAXIN-3 NEURONS IN THE NUCLEUS INCERTUS AND SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS
AJ Lawther, ML Clissold, S Ma, S Kent, CA Lowry, AL Gundlach, MW Hale
Anxiety is a complex and adaptive emotional state controlled by a distributed and interconnected network of brain regions, and dis..