ROLES FOR GASTRIN AND HYPOXIA IN COLORECTAL CANCER DEVELOPMENT
Grant number: 1062173 | Funding period: 2014 - 2016
Our objective is to understand how hormones such as gastrin stimulate the development of colorectal cancer. Our preliminary data shows that the amount of gastrin produced by tumour cells is increased by low oxygen. We will therefore study how the increase in gastrin in response to low oxygen causes a compensatory growth of the tumour. The ability to interfere with this process should allow us to slow tumour growth.
Related publications (4)
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer
David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin
BACKGROUND AND AIMS: Staging of colorectal cancer often fails to discriminate outcomes of patients with morphologically similar tu..
Retro-inverso forms of gastrin(5-12) are as biologically active as glycine-extended gastrin in vitro but not in vivo
Kathryn M Marshall, Marie Laval, Ioulia Sims, Arthur Shulkes, Graham S Baldwin
Non-amidated gastrin peptides such as glycine-extended gastrin (Ggly) are biologically active in vitro and in vivo and have been i..
Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions
Marie Laval, Graham S Baldwin, Arthur Shulkes, Kathryn M Marshall
Hypoxia, or a low concentration of O2, is encountered in humans undertaking activities such as mountain climbing and scuba diving ..
Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo
David A Westwood, Oneel Patel, Graham S Baldwin
AIM: Gastrins act as growth factors for the normal and neoplastic colorectal mucosa. The aim of this study was to determine the ro..