Roles For Gastrin And Hypoxia In Colorectal Cancer Development

Grant number: 1062173 | Funding period: 2014 - 2016

Completed

Abstract

Our objective is to understand how hormones such as gastrin stimulate the development of colorectal cancer. Our preliminary data shows that the amount of gastrin produced by tumour cells is increased by low oxygen. We will therefore study how the increase in gastrin in response to low oxygen causes a compensatory growth of the tumour. The ability to interfere with this process should allow us to slow tumour growth.