TUMOUR NECROSIS FACTOR SIGNALLING IN MOOD DISORDERS AND SCHIZOPHRENIA

Grant number: 1066144 | Funding period: 2014 - 2016

Completed

Abstract

Changes in inflammation-related pathways contribute to the symptoms of psychiatric disorders and tumour necrosis factor ? (TNF) is a protein central to regulating theses pathways. We have now shown that changes in pathways regulated by TNF are present in the brains of people with schizophrenia and mood disorders. This means that the symptoms experienced by those with the different disorders may be linked to differential changes in TNF-regulated pathways in the brain.

Related publications (5)

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Muscarinic receptor binding changes in postmortem Parkinson's disease

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Parkinson's disease (PD) is a devastating disorder, affecting approximately 2% of people aged 60 and above. It is marked by progre..

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Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

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2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25years ago. This review focusses on lines of research that have used tis..

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Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants

Andrew Stuart Gibbons, Won Je Jeon, Elizabeth Scarr, Brian Dean

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BACKGROUND: Increasingly, data are implicating muscarinic receptors in the aetiology and treatment of mood disorders. This led us ..

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Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia

Caitlin E McOmish, Geoff Pavey, Andrew Gibbons, Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean

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INTRODUCTION: The glutamatergic system has recently been implicated in the pathogenesis and treatment of major depressive disorder..

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The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?

Won Je Jeon, Brian Dean, Elizabeth Scarr, Andrew Gibbons

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The central cholinergic system has been implicated in the pathophysiology of mood disorders. An imbalance in central cholinergic n..

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