UNDERSTANDING HOW BACTERIA CAUSE PERSISTENT INFECTION
Grant number: 1066791 | Funding period: 2014 - 2017
Golden staph still causes significant human infections and resistance to antibiotics is an ever growing problem with this bacteria. This project will determine how resistance to some antibiotics is also changing the bacteria to promote persistent, difficult to treat infections. The insights from this study will help understand evolution of this bacteria, and help design new strategies for management.
Related publications (8)
Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis
Tania Wong Fok Lung, Ian R Monk, Karen P Acker, Andre Mu, Nancy Wang, Sebastian A Riquelme, Silvia Pires, Loreani P Noguera, Felix Dach, Stanislaw J Gabryszewski, Benjamin P Howden, Alice Prince
Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic infection, yet they lack expression of m..
Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification
Jean YH Lee, Glen P Carter, Sacha J Pidot, Romain Guerillot, Torsten Seemann, Anders Goncalves da Silva, Timothy J Foster, Benjamin P Howden, Timothy P Stinear, Ian R Monk
Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered..
Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections
Romain Guerillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R Monk, Mayu Kunimoto, Lora Starrs, Gaetan Burgio, Torsten Seemann, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden
Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic and persistent infections despite active ..
Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis
Jean YH Lee, Ian R Monk, Anders Goncalves da Silva, Torsten Seemann, Kyra YL Chua, Angela Kearns, Robert Hill, Neil Woodford, Mette D Bartels, Birgit Strommenger, Frederic Laurent, Magali Dodemont, Ariane Deplano, Robin Patel, Anders R Larsen, Tony M Korman, Timothy P Stinear, Benjamin P Howden
Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. e..
Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)
Romain Guerillot, Lucy Li, Sarah Baines, Brian Howden, Mark B Schultz, Torsten Seemann, Ian Monk, Sacha J Pidot, Wei Gao, Stefano Giulieri, Anders Goncalves da Silva, Anthony D'Agata, Takehiro Tomita, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden
Mutation acquisition is a major mechanism of bacterial antibiotic resistance that remains insufficiently characterised. Here we pr..
Comprehensive antibiotic-linked mutation assessment by Resistance Mutation Sequencing (RM-seq)
Romain Guérillot, Lucy Li, Sarah Baines, Brian Howden, Mark Schultz, Torsten Seemann, Ian Monk, Sacha Pidot, Wei Gao, Stefano Giulieri, Anders Gonçalves da Silva, Anthony D’Agata, Takehiro Tomita, Anton Peleg, Timothy Stinear, Benjamin Howden
<h4>ABSTRACT</h4> Acquired mutations are a major mechanism of bacterial antibiotic resistance generation and dissemination, and ca..
Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant &ITStaphylococcus aureus&IT
Romain Guerillot, Anders Goncalves da Silva, Ian Monk, Stefano Giulieri, Takehiro Tomita, Eloise Alison, Jessica Porter, Sacha Pidot, Wei Gao, Anton Y Peleg, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Mutations in the beta-subunit of bacterial RNA polymerase (RpoB) cause resistance to rifampin (Rifr), a critical antibiotic for tr..
Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis
Jean YH Lee, Ian R Monk, Sacha J Pidot, Siddarth Singh, Kyra YL Chua, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Staphylococcus epidermidis is a significant opportunistic pathogen of humans. The ST2 lineage is frequently multidrug-resistant an..