HOW THE IMMUNE SYSTEM CONTROLS VIRAL INFECTIONS AND CANCER
Grant number: 1059126 | Funding period: 2014 - 2019
The immune system is the essential complex barrier that protects the organism for infections and some malignancies. Despite considerable efforts, the mechanism by which immune cells kill dangerous unwanted cells is poorly understood. This project will investigate the mechanism of action and the role in human pathologies of a key component of the immune system, a toxic protein perforin.
Related publications (6)
Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis
Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik
Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry
Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani
Lipid order and charge protect killer T cells from accidental death
Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik
Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..
Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing
Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik
Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome
Stephen Opat, Anna C Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P Schwarer, Tahereh Noori, Joseph A Trapani, Anthony Jaworowski, Ilia Voskoboinik