HOW THE IMMUNE SYSTEM CONTROLS VIRAL INFECTIONS AND CANCER

Grant number: 1059126 | Funding period: 2014 - 2019

Completed

Abstract

The immune system is the essential complex barrier that protects the organism for infections and some malignancies. Despite considerable efforts, the mechanism by which immune cells kill dangerous unwanted cells is poorly understood. This project will investigate the mechanism of action and the role in human pathologies of a key component of the immune system, a toxic protein perforin.

Related publications (6)

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Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

2020-04-27

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Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani

2020-02-20

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Lipid order and charge protect killer T cells from accidental death

Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik

2019-11-27

Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..

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Neonatal Cytomegalovirus Palatal Ulceration and Bocavirus Pneumonitis Associated With a Defect of Lymphocyte Cytotoxicity Caused by Mutations in UNC13D

Paul Edgar Gray, Bella Shadur, Susan Russell, Richard Mitchell, Kerri Gallagher, Kevin Thia, Pamela Palasanthiran, Ilia Voskoboinik

2019-03-01

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Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik

2018-03-15

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Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome

Stephen Opat, Anna C Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P Schwarer, Tahereh Noori, Joseph A Trapani, Anthony Jaworowski, Ilia Voskoboinik

2018-02-08