IMMUNITY TO INTRACELLULAR INFECTIONS

Grant number: 1059861 | Funding period: 2014 - 2018

Completed

Abstract

This immune system provides our body’s defense against invading organisms like viruses, preventing disease and maintaining health. Immunity involves the interaction of several different cell types that together form arsenals tailored to combat each different infection. Professor Heath will investigate how cells of the immune system orchestrate effective immune responses to viral infections and malaria. He will use this understanding to design novel approaches to vaccination.

Related publications (3)

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CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

2018-10-02

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoi..

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CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Jessica Li, Fatma Ahmet, Meredith O'Keeffe, Mireille H Lahoud, William R Heath, Irina Caminschi

2017-01-01

We have previously shown that DEC205, a surface receptor expressed at high levels on CD8+DC, is able to capture synthetic CpG olig..

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CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden

2014-05-01

To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR tra..

University of Melbourne Researchers