DENDRITIC CELLS AND ANTIGEN PRESENTATION
Grant number: 1058193 | Funding period: 2014 - 2018
José Villadangos studies the cells and molecules involved in Antigen Presentation. This phenomenon consists of the detection, capture and display of microbe fragments on the surface of Antigen Presenting Cells (APC) for recognition by T cells. This initiates an immune response that culminates in the deployment of cells and molecules armed to fight the infection. His research may lead to development of more effective vaccines and prevention of autoimmunity, allergy and transplant rejection.
Related publications (6)
Physiological Substrates and Ontogeny-Specific Expression of the Ubiquitin Ligases MARCH1 and MARCH8
Patrick Schriek, Haiyin Liu, Alan C Ching, Pauline Huang, Nishma Gupta, Kayla R Wilson, MinHsuang Tsai, Yuting Yan, Christophe F Macri, Laura F Dagley, Giuseppe Infusini, Andrew I Webb, Hamish McWilliam, Satoshi Ishido, Justine D Mintern, Jose A Villadangos
<jats:title>ABSTRACT</jats:title><jats:p>MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of cr..
CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.
Nicholas A Gherardin, Samuel J Redmond, Hamish EG McWilliam, Catarina F Almeida, Katherine HA Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J Ross, Catriona V Nguyen-Robertson, Shian Su, Matthew E Ritchie, Jose A Villadangos, D Branch Moody, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey
CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool...
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos
The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..
Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection
Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern
Major histocompatibility complex class II (MHC II) expression is tightly regulated, being subjected to cell type-specific mechanis..