DENDRITIC CELLS AND ANTIGEN PRESENTATION
Grant number: 1058193 | Funding period: 2014 - 2018
José Villadangos studies the cells and molecules involved in Antigen Presentation. This phenomenon consists of the detection, capture and display of microbe fragments on the surface of Antigen Presenting Cells (APC) for recognition by T cells. This initiates an immune response that culminates in the deployment of cells and molecules armed to fight the infection. His research may lead to development of more effective vaccines and prevention of autoimmunity, allergy and transplant rejection.
Related publications (14)
A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells
Hui Jing Lim, Jacinta M Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey YW Mak, Abderrahman Hachani, Regan J Anderson, Gavin F Painter, Jesse Goyette, Shanika L Amarasinghe, Matthew E Ritchie, Antoine Roquilly, David P Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A Villadangos, Hamish EG McWilliam
MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from div..
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86
Haiyin Liu, Kayla R Wilson, Ashley M Firth, Christophe Macri, Patrick Schriek, Annabelle B Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish EG McWilliam, Andrew F Hill, Laura E Edgington-Mitchell, Irina Caminschi, Mireille H Lahoud, Elodie Segura, Marco J Herold, Jose A Villadangos, Justine D Mintern
The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, mo..
Marginal zone B cells acquire dendritic cell functions by trogocytosis
Patrick Schriek, Alan C Ching, Nagaraj S Moily, Jessica Moffat, Lynette Beattie, Thiago M Steiner, Laine M Hosking, Joshua M Thurman, V Michael Holers, Satoshi Ishido, Mireille H Lahoud, Irina Caminschi, William R Heath, Justine D Mintern, Jose A Villadangos
Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, anti..
MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues
Tony Yao, Patrick T Rudak, Celine M Laumont, Alex R Michaud, Rasheduzzaman Rashu, Natasha N Knier, Paula J Foster, Hamish EG McWilliam, Jose A Villadangos, Brad H Nelson, Gabriel E DiMattia, Trevor G Shepherd, SM Mansour Haeryfar
The low mutational burden of epithelial ovarian cancer (EOC) is an impediment to immunotherapies that rely on conventional MHC-res..
Varicella Zoster Virus Impairs Expression of the Nonclassical Major Histocompatibility Complex Class I-Related Gene Protein (MR1)
Shivam K Purohit, Carolyn Samer, Hamish EG McWilliam, Renee Traves, Megan Steain, Brian P McSharry, Paul R Kinchington, David C Tscharke, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
The antigen presentation molecule MR1 (major histocompatibility complex, class I-related) presents ligands derived from the ribofl..
MHC Class II Ubiquitination Regulates Dendritic Cell Function and Immunity
Kayla R Wilson, Devi Jenika, Annabelle B Blum, Christophe Macri, Bangyan Xu, Haiyin Liu, Patrick Schriek, Dominik Schienstock, Lauren Francis, F Victor Makota, Satoshi Ishido, Scott N Mueller, Mireille H Lahoud, Irina Caminschi, Laura E Edgington-Mitchell, Jose A Villadangos, Justine D Mintern
MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4+ T cell immunity. Cell surface levels of MHC II..
CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.
Nicholas A Gherardin, Samuel J Redmond, Hamish EG McWilliam, Catarina F Almeida, Katherine HA Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J Ross, Catriona V Nguyen-Robertson, Shian Su, Matthew E Ritchie, Jose A Villadangos, D Branch Moody, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey
CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool...
Physiological Substrates and Ontogeny-Specific Expression of the Ubiquitin Ligases MARCH1 and MARCH8
Patrick Schriek, Haiyin Liu, Alan C Ching, Pauline Huang, Nishma Gupta, Kayla R Wilson, MinHsuang Tsai, Yuting Yan, Christophe F Macri, Laura F Dagley, Giuseppe Infusini, Andrew I Webb, Hamish McWilliam, Satoshi Ishido, Justine D Mintern, Jose A Villadangos
<jats:title>ABSTRACT</jats:title><jats:p>MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of cr..
Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8.
Patrick Schriek, Haiyin Liu, Alan C Ching, Pauline Huang, Nishma Gupta, Kayla R Wilson, MinHsuang Tsai, Yuting Yan, Christophe F Macri, Laura F Dagley, Giuseppe Infusini, Andrew I Webb, Hamish EG McWilliam, Satoshi Ishido, Justine D Mintern, Jose A Villadangos
MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors. Understanding of ..
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos
The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..
Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4( ) T Cells
Haiyin Liu, Kayla R Wilson, Patrick Schriek, Christophe Macri, Annabelle B Blum, Lauren Francis, Melanie Heinlein, Champa Nataraja, James Harris, Sarah A Jones, Daniel HD Gray, Jose A Villadangos, Justine D Mintern
MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitin..
Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection
Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern
Major histocompatibility complex class II (MHC II) expression is tightly regulated, being subjected to cell type-specific mechanis..