Grant number: 1058635 | Funding period: 2014 - 2018
Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the world first, international clinical trial of very early rehabilitation for people with stroke (AVERT), which has the potential to reduce the global disability burden of this disease; 2) in a new acute exercise laboratory, complete studies that help refine existing early exercise interventions and 3) test new models of rehabilitation care that take advantage of advanced e-health capability.
Related publications (35)
Factors associated with time to independent walking recovery post-stroke.
Caitlin Kennedy, Julie Bernhardt, Leonid Churilov, Janice M Collier, Fiona Ellery, Venesha Rethnam, Lilian B Carvalho, Geoffrey A Donnan, Kathryn S Hayward
BACKGROUND: Past studies have inconsistently identified factors associated with independent walking post-stroke. We investigated t..
How can stroke care be improved for younger service users? A qualitative study on the unmet needs of younger adults in inpatient and outpatient stroke care in Australia
Jessica Shipley, Julie Luker, Vincent Thijs, Julie Bernhardt
Background: The incidence of young stroke is increasing worldwide. However, young adults are inadequately supported in their recov..
Exploring post acute rehabilitation service use and outcomes for working age stroke survivors (<= 65 years) in Australia, UK and South East Asia: data from the international AVERT trial
Rosy Walters, Janice M Collier, Lillian Braighi Carvalho, Peter Langhorne, Md Ali Katijjahbe, Dawn Tan, Marj Moodie, Julie Bernhardt
OBJECTIVES: Information about younger people of working age (≤65 years), their post stroke outcomes and rehabilitation pathways ca..
A Stroke Recovery Trial Development Framework: Consensus-Based Core Recommendations from the Second Stroke Recovery and Rehabilitation Roundtable
Julie Bernhardt, Kathryn S Hayward, Numa Dancause, Natasha A Lannin, Nick S Ward, Randolph J Nudo, Amanda Farrin, Leonid Churilov, Lara A Boyd, Theresa A Jones, S Thomas Carmichael, Dale Corbett, Steven C Cramer
A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to e..
Characterising Arm Recovery in People with Severe Stroke (CARPSS): protocol for a 12-month observational study of clinical, neuroimaging and neurophysiological biomarkers
Kathryn S Hayward, Keith R Lohse, Julie Bernhardt, Catherine E Lang, Lara A Boyd
INTRODUCTION: In individuals with early (indexed ≤7 days poststroke) and severe upper limb paresis (shoulder abduction and finger ..
A mixed-methods study to explore opinions of research translation held by researchers working in a Centre of Research Excellence in Australia
Elizabeth A Lynch, Shanthi A Ramanathan, Sandy Middleton, Julie Bernhardt, Michael Nilsson, Dominique A Cadilhac
OBJECTIVE: There is a growing need for researchers to demonstrate impact, which is reliant on successful research translation. The..
Breaking Up Sitting Time After Stroke - Reducing blood pressure through sitting less (BUST-BP-Dose): A trial protocol
Paul Mackie, Gary Crowfoot, Heidi Janssen, David Dunstan, Julie Bernhardt, Rohan Walker, Amanda Patterson, Robin Callister, Neil Spratt, Elizabeth Holliday, Coralie English
Implementing a protocol for a research impact assessment of the Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery
Shanthi Ramanathan, Penny Reeves, Simon Deeming, Julie Bernhardt, Michael Nilsson, Dominique A Cadilhac, Frederick Rohan Walker, Leeanne Carey, Sandy Middleton, Elizabeth Lynch, Andrew Searles
BACKGROUND: There is growing recognition that the wider benefits of research (economic, social and health impacts) should be asses..
Therapy fidelity results in an international aphasia therapy trial of a complex intervention in patients with stroke (The VERSE Trial)
Erin Godecke, Natalie Ciccone, Beth Armstrong, Fiona Ellery, Tapan Rai, Miranda Rose, Anne Whitworth, Audrey Holland, Sandy Middleton, Graeme Hankey, Dominique Cadilhac, Julie Bernhardt
How to do health services research in stroke: A focus on performance measurement and quality improvement
Dominique A Cadilhac, Rebecca Fisher, Julie Bernhardt
The objective of this "How to" research series article is to provide guidance on getting started in Health Services Research. The ..
Rationale for Intervention and Dose Is Lacking in Stroke Recovery Trials: A Systematic Review
Karen Borschmann, Kathryn S Hayward, Audrey Raffelt, Leonid Churilov, Sharon Kramer, Julie Bernhardt
Background: The ineffectiveness of most complex stroke recovery trials may be explained by inadequate intervention design. The pri..
Validity of Multisensor Array for Measuring Energy Expenditure of an Activity Bout in Early Stroke Survivors
Sharon Flora Kramer, Liam Johnson, Julie Bernhardt, Toby Cumming
Introduction. Stroke survivors use more energy than healthy people during activities such as walking, which has consequences for t..
Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke
Kathryn S Hayward, Julia Schmidt, Keith R Lohse, Sue Peters, Julie Bernhardt, Natasha A Lannin, Lara A Boyd
To build an understanding of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke, we con..
Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)
Julie Bernhardt, Leonid Churilov, Fiona Ellery, Janice Collier, Jan Chamberlain, Peter Langhorne, Richard I Lindley, Marj Moodie, Helen Dewey, Amanda G Thrift, Geoff Donnan
OBJECTIVE: Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance ..
Economic Evaluation Plan (EEP) for A Very Early Rehabilitation Trial (AVERT): An international trial to compare the costs and cost-effectiveness of commencing out of bed standing and walking training (very early mobilization) within 24h of stroke onset with usual stroke unit care
Lauren Sheppard, Helen Dewey, Julie Bernhardt, Janice M Collier, Fiona Ellery, Leonid Churilov, Kiu Tay-Teo, Olivia Wu, Marj Moodie
RATIONALE: A key objective of A Very Early Rehabilitation Trial is to determine if the intervention, very early mobilisation follo..
Moving rehabilitation research forward: Developing consensus statements for rehabilitation and recovery research
Julie Bernhardt, Karen Borschmann, Lara Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer, Tammy Hoffmann, Gert Kwakkel, Sean I Savitz, Gustavo Saposnik, Marion Walker, Nick Ward
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a nu..
Exploring the Role of Accelerometers in the Measurement of Real World Upper-Limb Use After Stroke
Kathryn S Hayward, Janice J Eng, Lara A Boyd, Bimal Lakhani, Julie Bernhardt, Catherine E Lang
The ultimate goal of upper-limb rehabilitation after stroke is to promote real-world use, that is, use of the paretic upper-limb i..
Reducing Sitting Time After Stroke: A Phase II Safety and Feasibility Randomized Controlled Trial
Coralie English, Genevieve N Healy, Tim Olds, Gaynor Parfitt, Erika Borkoles, Alison Coates, Sharon Kramer, Julie Bernhardt
OBJECTIVE: To test the safety, feasibility, and effectiveness of reducing sitting time in stroke survivors. DESIGN: Randomized con..
Sitting time and physical activity after stroke: physical ability is only part of the story
Coralie English, Genevieve N Healy, Alison Coates, Lucy K Lewis, Tim Olds, Julie Bernhardt
BACKGROUND: Understanding factors that influence the amount of time people with stroke spend sitting and being active is important..
Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial
Julie Bernhardt, Peter Langhorne, Richard I Lindley, Amanda G Thrift, Fiona Ellery, Janice Collier, Leonid Churilov, Marjory Moodie, Helen Dewey, Geoffrey Donnan
BACKGROUND: Early mobilisation after stroke is thought to contribute to the effects of stroke-unit care; however, the intervention..
Circuit class therapy or seven-day week therapy for increasing rehabilitation intensity of therapy after stroke (CIRCIT): a randomized controlled trial
Coralie English, Julie Bernhardt, Maria Crotty, Adrian Esterman, Leonie Segal, Susan Hillier
BACKGROUND: Increased therapy has been linked to improvements in functional ability of people with stroke. AIM: To determine the e..
Carers' experiences, needs and preferences during inpatient stroke rehabilitation: a protocol for a systematic review of qualitative studies
Julie A Luker, Susanne Bernhardsson, Elizabeth Lynch, Carolyn Murray, Olivia P Hill, Julie Bernhardt
BACKGROUND: Large numbers of people provide carer roles for survivors of stroke. Person-centred stroke rehabilitation must conside..
Statistical analysis plan (SAP) for A Very Early Rehabilitation Trial (AVERT): an international trial to determine the efficacy and safety of commencing out of bed standing and walking training (very early mobilization) within 24 h of stroke onset vs. usual stroke unit care
Julie Bernhardt, Leonid Churilov, Helen Dewey, Richard I Lindley, Marj Moodie, Janice Collier, Peter Langhorne, Amanda G Thrift, Geoffrey Donnan
Currently, the acute stroke interventions for which there is evidence of efficacy are stroke unit care (a complex package), select..
Sedentary behaviour and physical activity of people with stroke in rehabilitation hospitals.
Anna Sjöholm, Monica Skarin, Leonid Churilov, Michael Nilsson, Julie Bernhardt, Thomas Lindén
Background. Sedentary behaviour is associated with health risks, independent of physical activity. This study aimed to investigate..