Intergenerational transmission of gender-specific metabolic disease for offspring born small: maternal, paternal and embryonic roles
Grant number: 1045602 | Funding period: 2013 - 2015
This proposal addresses the underlying metabolic health consequences of poor embryo and growth of the baby across generations. We will define mechanisms by which a poor functioning placenta during a rat mother’s pregnancy programs her offspring born small to transmit gender-specific diseases to the next generation. We will identify mechanistic pathways involved, specifically the relative contributions of maternal and paternal germ lines and adverse maternal adaptations to pregnancy for females born small.
Related publications (9)
Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes
Dayana Mahizir, Jessica F Briffa, Jennifer L Wood, Kristina Anevska, Elisa L Hill-Yardin, Andrew J Jefferies, Sogand Gravina, Gisella Mazzarino, Ashley E Franks, Karen M Moritz, Glenn D Wadley, Mary E Wlodek
Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly prevalent in obese women. Importantly, exerci..
Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet
Kristina Anevska, Dayana Mahizir, Jessica E Briffa, Andrew J Jefferies, John D Wark, Brian L Grills, Rhys D Brady, Stuart J McDonald, Mary E Wlodek, Tania Romano
Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We a..
Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression
Yeukai TM Mangwiro, James SM Cuffe, Dayana Mahizir, Kristina Anevska, Sogand Gravina, Tania Romano, Karen M Moritz, Jessica F Briffa, Mary E Wlodek
KEY POINTS: Fetal growth is dependent on effective placental nutrient transportation, which is regulated by mammalian target of ra..
The transgenerational effect of maternal and paternal F1 low birth weight on bone health of second and third generation offspring
K Anevska, JD Wark, ME Wlodek, T Romano
Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and tran..
Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner
Yeukai TM Mangwiro, Jessica F Briffa, Sogand Gravina, Dayana Mahizir, Kristina Anevska, Tania Romano, Karen M Moritz, James SM Cuffe, Mary E Wlodek
Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous netw..
Maternal exercise in rats upregulates the placental insulin-like growth factor system with diet- and sex-specific responses: minimal effects in mothers born growth restricted
Yeukai TM Mangwiro, James SM Cuffe, Jessica F Briffa, Dayana Mahizir, Kristina Anevska, Andrew J Jefferies, Sogand Hosseini, Tania Romano, Karen M Moritz, Mary E Wlodek
KEY POINTS: The placental insulin-like growth factor (IGF) system is critical for normal fetoplacental growth, which is dysregulat..
Respiratory modulation of sympathetic nerve activity is enhanced in male rat offspring following uteroplacental insufficiency
C Menuet, ME Wlodek, AY Fong, AM Allen
Sympathetic nerve activity to the cardiovascular system displays prominent respiratory-related modulation which leads to the gener..
Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development
Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek
Low birth weight is associated with an increased risk for adult disease development with recent studies highlighting transmission ..
Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats
Jordanna S Master, Monika A Zimanyi, Kom V Yin, Karen M Moritz, Linda A Gallo, Melanie Tran, Mary E Wlodek, Mary J Black
Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subse..