MODELLING THE HUMAN NERVOUS SYSTEM WITH HUMAN PLURIPOTENT STEM CELLS

Grant number: FT130100514 | Funding period: 2014 - 2018

Completed

Abstract

The human nervous system is one of the most complex structures evolved to date. In order to understand how it functions, and dysfunctions in a diseased state, it is fundamental to decipher how it develops to generate various neuronal populations that form this elaborate network. Human stem cells provide a valuable source to study such processes. The aim of this project is to use human stem cells to study how early progenitor cell types that structure the nervous system are generated and how their neuronal derivatives form connectivity and functional synapses. The outcome of these studies is that we will establish a cellular model of human neurogenesis that can be utilised to study developmen..

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Related publications (4)

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Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies

Serena Viventi, Mirella Dottori

2018-07-01

Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperatu..

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Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate

Cristiana Mattei, Abdullah Alshawaf, Giovanna D'Abaco, Bryony Nayagam, Mirella Dottori

2018-04-16

Progress in aeronautics and spaceflight technologies requires in parallel further research on how microgravity may affect human ti..

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Graphene foam as a biocompatible scaffold for culturing human neurons

Giovanna M D'Abaco, Cristiana Mattei, Baba K Nasr, Emma J Hudson, Abdullah J Alshawaf, Gursharan Chana, Ian P Everall, Bryony Nayagam, Mirella Dottori, Efstratios Skafidas

2018-03-01

In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Hum..

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Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells

Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori

2018-01-12

The dorsal root ganglia (DRG) consist of a multitude of sensory neuronal subtypes that function to relay sensory stimuli, includin..

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