MODELLING THE HUMAN NERVOUS SYSTEM WITH HUMAN PLURIPOTENT STEM CELLS
Grant number: FT130100514 | Funding period: 2014 - 2018
The human nervous system is one of the most complex structures evolved to date. In order to understand how it functions, and dysfunctions in a diseased state, it is fundamental to decipher how it develops to generate various neuronal populations that form this elaborate network. Human stem cells provide a valuable source to study such processes. The aim of this project is to use human stem cells to study how early progenitor cell types that structure the nervous system are generated and how their neuronal derivatives form connectivity and functional synapses. The outcome of these studies is that we will establish a cellular model of human neurogenesis that can be utilised to study developmen..View full description
Related publications (4)
Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate
Cristiana Mattei, Abdullah Alshawaf, Giovanna D'Abaco, Bryony Nayagam, Mirella Dottori
Progress in aeronautics and spaceflight technologies requires in parallel further research on how microgravity may affect human ti..
Graphene foam as a biocompatible scaffold for culturing human neurons
Giovanna M D'Abaco, Cristiana Mattei, Baba K Nasr, Emma J Hudson, Abdullah J Alshawaf, Gursharan Chana, Ian P Everall, Bryony Nayagam, Mirella Dottori, Efstratios Skafidas
In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Hum..
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori
The dorsal root ganglia (DRG) consist of a multitude of sensory neuronal subtypes that function to relay sensory stimuli, includin..