BREAKING IT DOWN: DISSECTING THE MECHANISM AND EXPLORING NEW INHIBITION STRATEGIES FOR POLYSACCHARIDE CLEAVING ENZYMES

Grant number: FT130100103 | Funding period: 2014 - 2017

Completed

Abstract

Mannose, a common carbohydrate building block, is present in a wide variety of complex polysaccharides including energy storage polymers and glycans attached to proteins. The enzymes that degrade these mannose-rich polymers, termed mannosidases, are important in biofuel production and human health and disease. This project will study a range of mannosidases to chemically and structurally define their mechanisms and establish strategies to allow intervention in mannosidase-specific disease processes. This work will inform strategies to engineer new enzymes for future biotechnology and industrial applications including sustainable chemical manufacturing, and underpin the development of innovat..

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