DYNAMIC OCULAR IMAGING: NEW TOOLS TO STUDY NEURODEGENERATIVE DISEASE
Grant number: FT130100338 | Funding period: 2014 - 2018
Neurovascular uncoupling occurs when blood supply and energy production is no longer responsive to the metabolic of nervous tissue. Neurovascular uncoupling is thought to be a key mechanism in the development of debilitating neurodegenerative diseases such as Alzheimer’s disease and glaucoma. This project will be the first study to develop, validate and employ a comprehensive suite to simultaneously image blood flow, oxygen saturation, metabolic activity and retinal function to understand neurovascular uncoupling in aging and age-related neurodegeneration.
Related publications (9)
Application of Pattern Recognition Analysis to Optimize Hemifield Asymmetry Patterns for Early Detection of Glaucoma
Jack Phu, Sieu K Khuu, Bang Bui, Michael Kalloniatis
Purpose: To assess the diagnostic utility of a new hemifield asymmetry analysis derived using pattern recognition contrast sensiti..
Optic nerve tissue displacement during mild intraocular pressure elevation: its relationship to central corneal thickness and corneal hysteresis
Phillip Bedggood, Fumi Tanabe, Allison M McKendrick, Andrew Turpin, Andrew J Anderson, Bang V Bui
PURPOSE: To determine the extent to which (1) optic nerve tissue is displaced following mild acute elevation of intraocular pressu..
Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
Anna K van Koeverden, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression ..
A Method Using Goldmann Stimulus Sizes I to V-Measured Sensitivities to Predict Lead Time Gained to Visual Field Defect Detection in Early Glaucoma
Jack Phu, Sieu K Khuu, Bang V Bui, Michael Kalloniatis
Purpose: To predict the lead time (difference in time taken for a visual field [VF] defect to be detected) obtained when using sti..
How Many Subjects are Needed for a Visual Field Normative Database? A Comparison of Ground Truth and Bootstrapped Statistics
Jack Phu, Bang V Bui, Michael Kalloniatis, Sieu K Khuu
Purpose: The number of subjects needed to establish the normative limits for visual field (VF) testing is not known. Using bootstr..
Characterization of the Circumlimbal Suture Model of Chronic IOP Elevation in Mice and Assessment of Changes in Gene Expression of Stretch Sensitive Channels.
Da Zhao, Christine TO Nguyen, Vickie HY Wong, Jeremiah KH Lim, Zheng He, Andrew I Jobling, Erica L Fletcher, Holly R Chinnery, Algis J Vingrys, Bang V Bui
To consider whether a circumlimbal suture can be used to chronically elevate intraocular pressure (IOP) in mice and to assess its ..
Early Postnatal Hyperoxia in Mice Leads to Severe Persistent Vitreoretinopathy
Paul G McMenamin, Rachel Kenny, Sjakon Tahija, Jeremiah Lim, Cecilia Naranjo Golborne, Xiangting Chen, Sheena Bouch, Foula Sozo, Bang Bui
Purpose: To describe a mouse model of hyperoxia-induced vitreoretinopathy that replicated some of the clinical and pathologic feat..
The Eye As a Biomarker for Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Vickie HY Wong, Nicolas Currier, Jamie Mullen, Bang V Bui, Christine TO Nguyen
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading c..
Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy
Hsin-Hui Shen, Guei-Sheung Liu, Seong Hoong Chow, Jiang-Hui Wang, Zheng He, Christine Nguyen, Tsung-Wu Lin, Bang V Bui
Infrared (IR) spectroscopy has been used to quantify chemical and structural characteristics of a wide range of materials includin..