SITE-SPECIFIC CONJUGATION OF ZIRCONIUM AND COPPER COMPLEXES TO ANTIBODIES FOR APPLICATION IN DIAGNOSTIC IMAGING AND THERAPY
Grant number: FT130100204 | Funding period: 2014 - 2017
This project will focus on fundamental chemistry that underpins innovations in the synthesis of metal-based imaging and therapeutic agents. Radioactive isotopes of copper and zirconium can be used for either non-invasive diagnostic imaging or treatment of disease. However, it is essential that the diagnostic or therapeutic agent selectively localises in diseased tissue. This project aims to achieve the required selectivity by employing enzymatic site-specific bioconjugation reactions to build new imaging agents that feature ligands designed to safely bind radioactive isotopes fused to antibody derived targeting molecules.
Related publications (3)
Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK
Andrea J North, John A Karas, Michelle T Ma, Philip J Blower, Uwe Ackermann, Jonathan M White, Paul S Donnelly
A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates
Asif Noor, Jiawei Li, George N Khairallah, Zhen Li, Hossein Ghari, Allan J Canty, Alireza Ariafard, Paul S Donnelly, Richard AJ O'Hair
A new palladium mediated “one pot” synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was di..