Gene-environment interactions in the regulation of neuroplasticity and cognitive function

Grant number: DE140100588 | Funding period: 2014 - 2016

Completed

Abstract

This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understa..

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Related publications (8)

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What's wrong with my mouse cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in mice

Christina Mo, Thibault Renoir, Anthony J Hannan

2016-05-30

The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models us..

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Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment

J Rogers, U Vo, LS Buret, TY Pang, H Meiklejohn, A Zeleznikow-Johnston, L Churilov, M van den Buuse, AJ Hannan, T Renoir

2016-04-26

Clinical evidence indicates that serotonin-1A receptor (5-HT1AR) gene polymorphisms are associated with anxiety disorders and defi..

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Environmental factors as modulators of neurodegeneration: Insights from gene-environment interactions in Huntington's disease

Christina Mo, Anthony J Hannan, Thibault Renoir

2015-05-01

Unlike many other neurodegenerative diseases with established gene-environment interactions, Huntington's disease (HD) is viewed a..

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N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

DJ Wright, T Renoir, ZM Smith, AE Frazier, PS Francis, DR Thorburn, SL McGee, AJ Hannan, LJ Gray

2015-01-06

Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-re..

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The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

X Du, TY Pang, C Mo, T Renoir, DJ Wright, AJ Hannan

2015-01-01

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disease caused by a CAG tandem repeat mutation encoding a po..

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Sexually dimorphic dopaminergic dysfunction in a transgenic mouse model of Huntington's disease

Thibault Renoir, Andrew Argyropoulos, Caroline Chevarin, Laurence Lanfumey, Anthony J Hannan

2014-12-01

BACKGROUND: Using the R6/1 transgenic mouse model of Huntington's disease (HD), we have recently shown that acute administration w..

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Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice

Christina Mo, Thibault Renoir, Anthony J Hannan

2014-11-01

Huntington's disease (HD) is a neurodegenerative disease caused by a tandem repeat mutation encoding an expanded polyglutamine tra..

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Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress

Christina Mo, Thibault Renoir, Terence YC Pang, Anthony J Hannan

2013-09-15

Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive, psychiatric and motor decline, and is modifiable by..

University of Melbourne Researchers