Gamma delta T cells specific for glycolipid antigens

Abstract

Gamma delta T cells are an enigmatic component of the immune system that use a unique class of cell surface receptors (gamma delta T cell receptors). Despite having been discovered 30 years ago, very little is known about what these cells recognise and respond to, and therefore what is their function. A population of gamma delta T cells that respond via their T cell receptor to particular forms of lipid molecules presented by an antigen presenting molecule, CD1d has been identified. The aim of this project is to isolate these T cell receptors and investigate the interaction at the molecular level in order to understand the parameters that trigger activation of these cells. This will provide ..

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Lipid and small-molecule display by CD1 and MR1

Ildiko Van Rhijn, Dale I Godfrey, Jamie Rossjohn, D Branch Moody

2015-10-01

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The anti..