Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies
Grant number: DP140100002 | Funding period: 2014 - 2017
The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeuti..View full description
Related publications (6)
Highly Living Stars via Core-First Photo-RAFT Polymerization: Exploitation for Ultra-High Molecular Weight Star Synthesis
Stephanie Allison-Logan, Fatemeh Karimi, Yongkang Sun, Thomas G McKenzie, Mitchell D Nothling, Gary Bryant, Greg G Qiao
Star polymers are highly functional materials that display unique properties in comparison to linear polymers, making them valuabl..
Macroporous Hydrogels Composed Entirely of Synthetic Polypeptides: Biocompatible and Enzyme Biodegradable 3D Cellular Scaffolds
Steven J Shirbin, Fatemeh Karimi, Nicholas Jun-An Chan, Daniel E Heath, Greg G Qiao
Synthetic polypeptides are a class of bioinspired polymers with well demonstrated biocompatibility, enzyme biodegradability, and c..
Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure
Steven J Shirbin, Shu J Lam, Nicholas Jun-An Chan, Mehmet Murat Ozmen, Qiang Fu, Neil O'Brien-Simpson, Eric C Reynolds, Greg G Qiao
Synthetic polypeptide-based macroporous cryogels with inherent antimicrobial properties were prepared for potential water purifica..
Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery
Steven J Shirbin, Katharina Ladewig, Qiang Fu, Molly Klimak, Xiaoqing Zhang, Wei Duan, Greg G Qiao
Novel cisplatin (CDDP)-loaded, polypeptide-based vesicles for the targeted delivery of cisplatin to cancer cells have been prepare..
Aptamer-Mediated Cancer Gene Therapy
Dongxi Xiang, Sarah Shigdar, Greg Qiao, Shu-Feng Zhou, Yong Li, Ming Q Wei, Liang Qiao, Hadi Al Shamaileh, Yimin Zhu, Conglong Zheng, Chunwen Pu, Wei Duan
Cancer as a genetic disorder is one of the leading causes of death worldwide. Conventional anticancer options such as chemo- and/o..
Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine
Dongxi Xiang, Sarah Shigdar, Greg Qiao, Tao Wang, Abbas Z Kouzani, Shu-Feng Zhou, Lingxue Kong, Yong Li, Chunwen Pu, Wei Duan
Conventional anticancer therapies, such as chemo- and/or radio-therapy are often unable to completely eradicate cancers due to abn..