Chemical probes for the study of a unique enzyme from Mycobacterium tuberculosis

Structure-Activity Relationships of cyclo(L-Tyrosyl-L-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

Sunnia Rajput, Kirsty J McLean, Harshwardhan Poddar, Irwin R Selvam, Gayathri Nagalingam, James A Triccas, Colin W Levy, Andrew W Munro, Craig A Hutton

2019-11-14

A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium tuberculosis enzyme CYP121, have been syn..

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Soumya Mukherjee, Mengxuan Fang, W Mei Kok, Eugene A Kapp, Varsha J Thombare, Romain Huguet, Craig A Hutton, Gavin E Reid, Blaine R Roberts

2019-10-01

Dityrosine cross-linking of Aβ peptides and α-synuclein is increasingly becoming recognized as a biomarker of neuropathological di..

Bridged bicyclic peptides: Structure and function

Varsha J Thombare, Craig A Hutton

2018-05-01

Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, y..