Attacking Cancer Using a Unified Immune System

Tissue-dependent tumor microenvironments and their impact on immunotherapy responses

AJ Oliver, PKH Lau, AS Unsworth, S Loi, PK Darcy, MH Kershaw, CY Slaney

2018-01-31

Recent advances in cancer immunology have led to a better understanding of the role of the tumor microenvironment (TME) in tumor i..

Dual-specific chimeric antigen receptor T cells and an indirect vaccine eradicate a variety of large solid tumors in an immunocompetent, self-antigen setting

CY Slaney, B Von Scheidt, AJ Davenport, PA Beavis, JA Westwood, S Mardiana, DC Tscharke, S Ellis, HM Prince, JA Trapani, RW Johnstone, MJ Smyth, MW Teng, A Ali, Z Yu, SA Rosenberg, NP Restifo, P Neeson, PK Darcy, MH Kershaw

2017-05-15

Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some le..

CAR T-cell therapy of solid tumors

CSM Yong, V Dardalhon, C Devaud, N Taylor, PK Darcy, MH Kershaw

2017-04-01

The potential for immunotherapy as a treatment option for cancer is clear from remarkable responses of some leukemia patients to a..

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

CSM Yong, LB John, C Devaud, MH Prince, RW Johnstone, JA Trapani, PK Darcy, MH Kershaw

2016-06-07

While adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role ..