REMODELING OF THE RED BLOOD CELL DURING MALARIA PARASITE INVASION
Grant number: 1047085 | Funding period: 2014 - 2016
Malaria parasites cause profound human disease through infection of the red blood cell. How parasites break into the red cell is incompletely understood. Foremost, the parasite must induce radical changes in its structural integrity to enter, but to date no study has been able to precisely map these cellular events. In this research program we aim to dissect the entire process using state-of-the-art imaging, molecular biology and proteomics to shine new light on this key step in malaria disease establishment.
Related publications (4)
Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton
Elizabeth S Zuccala, Timothy J Satchwell, Fiona Angrisano, Yan Hong Tan, Marieangela C Wilson, Kate J Heesom, Jake Baum
The invasive blood-stage malaria parasite - the merozoite - induces rapid morphological changes to the target erythrocyte during e..
Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion
David T Riglar, Lachlan Whitehead, Alan F Cowman, Kelly L Rogers, Jake Baum
Microscopy-based localisation of proteins during malaria parasite (Plasmodium) invasion of the erythrocyte is widely used for tent..
Membrane-Wrapping Contributions to Malaria Parasite Invasion of the Human Erythrocyte
Sabyasachi Dasgupta, Thorsten Auth, Nir S Gov, Timothy J Satchwell, Eric Hanssen, Elizabeth S Zuccala, David T Riglar, Ashley M Toye, Timo Betz, Jake Baum, Gerhard Gompper
The blood stage malaria parasite, the merozoite, has a small window of opportunity during which it must successfully target and in..
Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion
Eric Hanssen, Chaitali Dekiwadia, David T Riglar, Melanie Rug, Leandro Lemgruber, Alan F Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum, Stuart A Ralph
Erythrocyte invasion by merozoites forms of the malaria parasite is a key step in the establishment of human malaria disease. To d..