Establishing the Use of Bacterial Genomics in Australia

Grant number: 1074824 | Funding period: 2014 - 2017

Completed

Abstract

We propose to establish a set of fully assembled reference genomes through new technologies and methods to analyse data from high throughput genome sequencing of important bacterial pathogens in Australia. We aim to demonstrate the capabilities of genome sequencing in clinical situations by comparing the genomes from clinical bacterial isolates to the established and annotated reference genomes.

Related publications (8)

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Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: An observational study

JC Kwong, EPF Chow, K Stevens, TP Stinear, T Seemann, CK Fairley, MY Chen, BP Howden

2018-03-01

Objectives: Drug-resistant Neisseria gonorrhoeae are now a global public health threat. Direct transmission of antibiotic-resistan..

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Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand

RS Lee, T Seemann, H Heffernan, JC Kwong, A Gonçalves Da Silva, GP Carter, R Woodhouse, KH Dyet, DM Bulach, TP Stinear, BP Howden, DA Williamson

2018-02-01

Background: Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the..

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Translating genomics into practice for real-time surveillance and response to carbapenemase-producing Enterobacteriaceae: Evidence from a complex multi-institutional KPC outbreak

JC Kwong, CR Lane, F Romanes, AG da Silva, M Easton, K Cronin, MJ Waters, T Tomita, K Stevens, MB Schultz, SL Baines, NL Sherry, GP Carter, A Mu, M Sait, SA Ballard, T Seemann, TP Stinear, BP Howden

2018-01-01

Background: Until recently, Klebsiella pneumoniae carbapenemase (KPC)- producing Enterobacteriaceae were rarely identified in Aust..

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A supervised statistical learning approach for accurate Legionella pneumophila source attribution during outbreaks

AH Buultjens, KYL Chua, SL Baines, J Kwong, W Gao, Z Cutcher, S Adcock, S Ballard, MB Schultz, T Tomita, N Subasinghe, GP Carter, SJ Pidot, L Franklin, T Seemann, AG Da Silva, BP Howden, TP Stinear

2017-11-01

Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative ba..

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Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring blaCTX-M-9

SJ Sparham, JC Kwong, M Valcanis, M Easton, DJ Trott, T Seemann, TP Stinear, BP Howden

2017-07-01

Antimicrobial resistance in non-typhoidal Salmonella is a critical problem globally, with the emergence of resistance to third-gen..

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NGMASTER:in silico multi-antigen sequence typing for Neisseria gonorrhoeae

JC Kwong, A Gonçalves da Silva, K Dyet, DA Williamson, TP Stinear, BP Howden, T Seemann

2016-08-01

Whole-genome sequencing (WGS) provides the highest resolution analysis for comparison of bacterial isolates in public health micro..

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Prospective whole-genome sequencing enhances national surveillance of listeria monocytogenes

JC Kwong, K Mercoulia, T Tomita, M Easton, HY Li, DM Bulach, TP Stinear, T Seemann, BP Howden

2016-02-01

Whole-genome sequencing (WGS) has emerged as a powerful tool for comparing bacterial isolates in outbreak detection and investigat..

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Whole genome sequencing in clinical and public health microbiology

JC Kwong, N Mccallum, V Sintchenko, BP Howden

2015-04-01

Genomics and whole genome sequencing (WGS) have the capacity to greatly enhance knowledge and understanding of infectious diseases..

University of Melbourne Researchers