PERSONALISED PROGNOSTIC TOOLS FOR EARLY PSYCHOSIS MANAGEMENT (PRONIA)

Grant number: 1075379 | Funding period: 2014 - 2019

Completed

Abstract

Psychosis can be a devastating illness with harmful long-term consequences, such as chronic schizophrenia. To avoid distress, deterioration, and potential disability, we need more accurate tools to personalise treatment for individuals by understanding their prognosis. The PRONIA project will help to improve methods of predicting outcomes by working with our European colleagues to create a cybernetic prognostic system for psychosis that uses brain imaging, genetics, cognition, and clinical markers.

Related publications (7)

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Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

Letizia Squarcina, Lana Kambeitz-Ilankovic, Carolina Bonivento, Cecilia Prunas, Lucio Oldani, Julian Wenzel, Anne Ruef, Dominic Dwyer, Adele Ferro, Stefan Borgwardt, Joseph Kambeitz, Theresa Katharina Lichtenstein, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Rachel Upthegrove, Linda A Antonucci, Alessandro Bertolino, Rebekka Lencer, Stephan Ruhrmann

2022-01-19

OBJECTIVE: Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in su..

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Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness

Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rossler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl

2021-09-14

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..

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Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes

David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi

2020-12-01

BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..

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Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

Helene Walger, Linda A Antonucci, Alessandro Pigoni, Rachel Upthegrove, Raimo KR Salokangas, Rebekka Lencer, Katharine Chisholm, Anita Riecher-Rossler, Theresa Haidl, Eva Meisenzahl, Marlene Rosen, Stephan Ruhrmann, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Peter Falkai, Anne Ruef, Jarmo Hietala, Christos Pantelis, Stephen J Wood, Paolo Brambilla

2020-11-17

In community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically rele..

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Validation of the Bullying Scale for Adults - Results of the PRONIA-study

Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz

2020-10-01

BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..

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Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression A Multimodal, Multisite Machine Learning Analysis

Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Stephan Ruhrmann, Marlene Rosen, Anne Ruef, Dominic B Dwyer, Marco Paolini, Katharine Chisholm, Joseph Kambeitz, Theresa Haidl, Andre Schmidt, John Gillam, Frauke Schultze-Lutter, Peter Falkai, Maximilian Reiser, Anita Riecher-Rossler, Rachel Upthegrove, Jarmo Hietala, Raimo KR Salokangas, Christos Pantelis

2018-11-01

IMPORTANCE: Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk str..

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Risk and resilience brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2018-03-01

BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..

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