CIRCULATING TUMOUR DNA AS A PERSONALISED BIOMARKER IN BREAST CANCER

Characterizing the Cancer Genome in Blood

Sarah-Jane Dawson

2019-04-01

Cell-free circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) can be found in the bloodstream of individuals with can..

The value of cell-free DNA for molecular pathology

Caitlin M Stewart, Prachi D Kothari, Florent Mouliere, Richard Mair, Saira Somnay, Ryma Benayed, Ahmet Zehir, Britta Weigelt, Sarah-Jane Dawson, Maria E Arcila, Michael F Berger, Dana WY Tsui

2018-04-01

Over the past decade, advances in molecular biology and genomics techniques have revolutionized the diagnosis and treatment of can..

Circulating Tumor DNA Guides Prognosis in Metastatic Triple-Negative Breast Cancer

Andjelija Zivanovic Bujak, Sarah-Jane Dawson

2018-02-20

Wet or Dry? Do Liquid Biopsy Techniques Compete with or Complement PET for Disease Monitoring in Oncology?

Stephen Q Wong, Richard W Tothill, Sarah-Jane Dawson, Rodney J Hicks

2017-06-01

Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer

Elizabeth L Christie, Sian Fereday, Ken Doig, Swetansu Pattnaik, Sarah-Jane Dawson, David DL Bowtell

2017-04-20

Purpose Germline BRCA1 or BRCA2 mutations in patients with high-grade serous ovarian cancer (HGSC) are associated with favorable r..

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

Paul Yeh, Michael Dickinson, Sarah Ftouni, Tane Hunter, Devbarna Sinha, Stephen Q Wong, Rishu Agarwal, Ravikiran Vedururu, Kenneth Doig, Chun Yew Fong, Piers Blombery, David Westerman, Mark A Dawson, Sarah-Jane Dawson

2017-03-23

The diagnosis and monitoring of myelodysplastic syndromes (MDSs) are highly reliant on bone marrow morphology, which is associated..

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman

2017-03-17

Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use ..

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE"

Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi

2016-12-01

BACKGROUND: Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients. Genomic assays are em..

Blood Worth Bottling: Circulating Tumor DNA as a Cancer Biomarker

Elizabeth L Christie, Sarah-Jane Dawson, David DL Bowtell

2016-10-01

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

Bernard Pereira, Suet-Feung Chin, Oscar M Rueda, Hans-Kristian Moen Vollan, Elena Provenzano, Helen A Bardwell, Michelle Pugh, Linda Jones, Roslin Russell, Stephen-John Sammut, Dana WY Tsui, Bin Liu, Sarah-Jane Dawson, Jean Abraham, Helen Northen, John F Peden, Abhik Mukherjee, Gulisa Turashvili, Andrew R Green, Steve McKinney

2016-05-01

The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating ..

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

M Ignatiadis, S-J Dawson

2014-12-01

Next-generation sequencing studies have provided further evidence to support the notion that cancer is a disease characterized by ..