TOOLS FOR ANALYSING BRAIN IMAGING DATA IN HEALTH AND DISEASE

The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders

Elysha Ringin, Vanessa Cropley, Andrew Zalesky, Jason Bruggemann, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Chad A Bousman, Christos Pantelis, Tamsyn E Van Rheenen

2021-01-14

BACKGROUND: Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. C..

Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders

Tamsyn E Van Rheenen, Vanessa Cropley, Birgitte Fagerlund, Cassandra Wannan, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Andrew Zalesky, Chad A Bousman, Christos Pantelis

2020-07-01

BACKGROUND: In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsi..

Building connectomes using diffusion MRI: why, how and but

Stamatios N Sotiropoulos, Andrew Zalesky

2019-04-01

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, ..

Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study

Nabi Zorlu, Necip Capraz, Esra Oztekin, Basak Bagci, Maria A Di Biase, Andrew Zalesky, Fazil Gelal, Emre Bora, Ercan Durmaz, Lutfullah Besiroglu, Aybala Saricicek

2019-03-01

We aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol u..

Personalized Transcranial Magnetic Stimulation in Psychiatry

Luca Cocchi, Andrew Zalesky

2018-09-01

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that allows for modulating the activity of lo..

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz

2018-09-01

INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..

Fragility and volatility of structural hubs in the human connectome

Leonardo L Gollo, James A Roberts, Vanessa L Cropley, Maria A Di Biase, Christos Pantelis, Andrew Zalesky, Michael Breakspear

2018-08-01

Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computati..

Minimum spanning tree analysis of the human connectome

Edwin van Dellen, Iris E Sommer, Marc M Bohlken, Prejaas Tewarie, Laurijn Draaisma, Andrew Zalesky, Maria Di Biase, Jesse A Brown, Linda Douw, Willem M Otte, Rene CW Mandl, Cornelis J Stam

2018-06-01

One of the challenges of brain network analysis is to directly compare network organization between subjects, irrespective of the ..

Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities

Tamsyn E Van Rheenen, Vanessa Cropley, Andrew Zalesky, Chad Bousman, Ruth Wells, Jason Bruggemann, Suresh Sundram, Danielle Weinberg, Roshel K Lenroot, Avril Pereira, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis

2018-05-01

OBJECTIVE: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterog..

Risk and resilience brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2018-03-01

BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..

Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls

Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky

2018-01-22

Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis

2018-01-01

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system...

Estimating the impact of structural directionality: How reliable are undirected connectomes?

Penelope Kale, Andrew Zalesky, Leonardo L Gollo

2018-01-01

Directionality is a fundamental feature of network connections. Most structural brain networks are intrinsically directed because ..

Transcranial magnetic stimulation in obsessive-compulsive disorder: A focus on network mechanisms and state dependence

Luca Cocchi, Andrew Zalesky, Zoie Nott, Genevieve Whybird, Paul B Fitzgerald, Michael Breakspear

2018-01-01

BACKGROUND: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has shown promise as an adj..

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

2017-12-01

BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..

Criticality in the brain: A synthesis of neurobiology, models and cognition

Luca Cocchi, Leonardo L Gollo, Andrew Zalesky, Michael Breakspear

2017-11-01

Cognitive function requires the coordination of neural activity across many scales, from neurons and circuits to large-scale netwo..

Track-weighted dynamic functional connectivity (TW-dFC): a new method to study time-resolved functional connectivity

Fernando Calamante, Robert E Smith, Xiaoyun Liang, Andrew Zalesky, Alan Connelly

2017-11-01

Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional co..

Reconfiguration of Brain Network Architectures between Resting-State and Complexity-Dependent Cognitive Reasoning

Luke J Hearne, Luca Cocchi, Andrew Zalesky, Jason B Mattingley

2017-08-30

Our capacity for higher cognitive reasoning has a measurable limit. This limit is thought to arise from the brain's capacity to fl..

Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging

Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki

2017-07-01

Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensiti..

Neural Decoding of Visual Stimuli Varies with Fluctuations in Global Network Efficiency

Luca Cocchi, Zhengyi Yang, Andrew Zalesky, Johannes Stelzer, Luke J Hearne, Leonardo L Gollo, Jason B Mattingley

2017-06-01

Functional magnetic resonance imaging (fMRI) studies have shown that neural activity fluctuates spontaneously between different st..

Accelerated Gray and White Matter Deterioration With Age in Schizophrenia

Vanessa L Cropley, Paul Klauser, Rhoshel K Lenroot, Jason Bruggemann, Suresh Sundram, Chad Bousman, Avril Pereira, Maria A Di Biase, Thomas W Weickert, Cynthia Shannon Weickert, Christos Pantelis, Andrew Zalesky

2017-03-01

OBJECTIVE: Although brain changes in schizophrenia have been proposed to mirror those found with advancing age, the trajectory of ..

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky

2017-03-01

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..

Opportunities and Challenges for Psychiatry in the Connectomic Era

Alex Fornito, Edward T Bullmore, Andrew Zalesky

2017-01-01

Most major psychiatric disorders arise from disturbances of anatomically distributed neural systems rather than isolated dysfuncti..

Connectome sensitivity or specificity: which is more important?

Andrew Zalesky, Alex Fornito, Luca Cocchi, Leonardo L Gollo, Martijn P van den Heuvel, Michael Breakspear

2016-11-15

Connectomes with high sensitivity and high specificity are unattainable with current axonal fiber reconstruction methods, particul..

A hierarchy of timescales explains distinct effects of local inhibition of primary visxc ual cortex and frontal eye fields

Luca Cocchi, Martin V Sale, Leonardo L Gollo, Peter T Bell, Vinh T Nguyen, Andrew Zalesky, Michael Breakspear, Jason B Mattingley

2016-09-06

Within the primate visual system, areas at lower levels of the cortical hierarchy process basic visual features, whereas those at ..

Hippocampal harms, protection and recovery following regular cannabis use

M Yuecel, V Lorenzetti, C Suo, A Zalesky, A Fornito, MJ Takagi, DI Lubman, N Solowij

2016-01-12

Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for healt..

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Martin V Sale, Jason B Mattingley, Andrew Zalesky, Luca Cocchi

2015-10-01

The flexible integration of segregated neural processes is essential to healthy brain function. Advances in neuroimaging technique..

Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings

Andrew Zalesky, Christos Pantelis, Vanessa Cropley, Alex Fornito, Luca Cocchi, Harrison McAdams, Liv Clasen, Deanna Greenstein, Judith L Rapoport, Nitin Gogtay

2015-09-01

IMPORTANCE: Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnorm..

Developmental Changes in Brain Network Hub Connectivity in Late Adolescence

Simon TE Baker, Dan I Lubman, Murat Yuecel, Nicholas B Allen, Sarah Whittle, Ben D Fulcher, Andrew Zalesky, Alex Fornito

2015-06-17

The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is th..

Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics

Luca Cocchi, Martin V Sale, Anton Lord, Andrew Zalesky, Michael Breakspear, Jason B Mattingley

2015-05-01

Normal brain function depends on a dynamic balance between local specialization and large-scale integration. It remains unclear, h..

A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS)

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Andrew Zalesky, Masaaki Hori, Keigo Shimoji, Junichi Saito, Shinya Ito, Dominic B Dwyer, Issei Fukunaga, Keiko Morita, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno

2015-03-01

BACKGROUND: Evidence supports disruption in white matter (WM) connectivity in established schizophrenia, however, it is unclear wh..

The connectomics of brain disorders

Alex Fornito, Andrew Zalesky, Michael Breakspear

2015-03-01

Pathological perturbations of the brain are rarely confined to a single locus; instead, they often spread via axonal pathways to i..

Disruption of brain white matter microstructure in women with anorexia nervosa

Esther Via, Andrew Zalesky, Isabel Sanchez, Laura Forcano, Ben J Harrison, Jesus Pujol, Fernando Fernandez-Aranda, Jose Manuel Menchon, Carles Soriano-Mas, Narcis Cardoner, Alex Fornito

2014-11-01

BACKGROUND: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its ..

Large-Scale Brain Network Dynamics Supporting Adolescent Cognitive Control

Dominic B Dwyer, Ben J Harrison, Murat Yuecel, Sarah Whittle, Andrew Zalesky, Christos Pantelis, Nicholas B Allen, Alex Fornito

2014-10-15

Adolescence is a time when the ability to engage cognitive control is linked to crucial life outcomes. Despite a historical focus ..

Time-resolved resting-state brain networks

Andrew Zalesky, Alex Fornito, Luca Cocchi, Leonardo L Gollo, Michael Breakspear

2014-07-15

Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation p..

Disruption of structure-function coupling in the schizophrenia connectome

Luca Cocchi, Ian H Harding, Anton Lord, Christos Pantelis, Murat Yucel, Andrew Zalesky

2014-01-01

Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functi..

Dynamic cooperation and competition between brain systems during cognitive control

Luca Cocchi, Andrew Zalesky, Alex Fornito, Jason B Mattingley

2013-10-01

The human brain is characterized by a remarkable ability to adapt its information processing based on current goals. This ability,..