TOOLS FOR ANALYSING BRAIN IMAGING DATA IN HEALTH AND DISEASE
Grant number: 1047648 | Funding period: 2014 - 2018
This research will develop cutting-edge computational tools and statistical methods to analyse, model and visualise the way in which the human brain is interconnected. The tools developed will be used to identify biological markers in the brain’s network of axonal circuitry (the connectome) that are valuable for diagnosis and prognosis of psychiatric disorders. This research will bring to fruition the exciting potential of connectomics in neuroscience and psychiatry.
Related publications (37)
The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders
Elysha Ringin, Vanessa Cropley, Andrew Zalesky, Jason Bruggemann, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Chad A Bousman, Christos Pantelis, Tamsyn E Van Rheenen
BACKGROUND: Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. C..
Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders
Tamsyn E Van Rheenen, Vanessa Cropley, Birgitte Fagerlund, Cassandra Wannan, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Andrew Zalesky, Chad A Bousman, Christos Pantelis
BACKGROUND: In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsi..
Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study
Nabi Zorlu, Necip Capraz, Esra Oztekin, Basak Bagci, Maria A Di Biase, Andrew Zalesky, Fazil Gelal, Emre Bora, Ercan Durmaz, Lutfullah Besiroglu, Aybala Saricicek
We aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol u..
Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz
INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..
Fragility and volatility of structural hubs in the human connectome
Leonardo L Gollo, James A Roberts, Vanessa L Cropley, Maria A Di Biase, Christos Pantelis, Andrew Zalesky, Michael Breakspear
Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computati..
Minimum spanning tree analysis of the human connectome
Edwin van Dellen, Iris E Sommer, Marc M Bohlken, Prejaas Tewarie, Laurijn Draaisma, Andrew Zalesky, Maria Di Biase, Jesse A Brown, Linda Douw, Willem M Otte, Rene CW Mandl, Cornelis J Stam
One of the challenges of brain network analysis is to directly compare network organization between subjects, irrespective of the ..
Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities
Tamsyn E Van Rheenen, Vanessa Cropley, Andrew Zalesky, Chad Bousman, Ruth Wells, Jason Bruggemann, Suresh Sundram, Danielle Weinberg, Roshel K Lenroot, Avril Pereira, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis
OBJECTIVE: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterog..
Risk and resilience brain networks in treatment-resistant schizophrenia
Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..
Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls
Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky
Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..
Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system...
Transcranial magnetic stimulation in obsessive-compulsive disorder: A focus on network mechanisms and state dependence
Luca Cocchi, Andrew Zalesky, Zoie Nott, Genevieve Whybird, Paul B Fitzgerald, Michael Breakspear
BACKGROUND: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has shown promise as an adj..
White matter connectivity disruptions in early and chronic schizophrenia
MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky
BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..
Track-weighted dynamic functional connectivity (TW-dFC): a new method to study time-resolved functional connectivity
Fernando Calamante, Robert E Smith, Xiaoyun Liang, Andrew Zalesky, Alan Connelly
Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional co..
Reconfiguration of Brain Network Architectures between Resting-State and Complexity-Dependent Cognitive Reasoning
Luke J Hearne, Luca Cocchi, Andrew Zalesky, Jason B Mattingley
Our capacity for higher cognitive reasoning has a measurable limit. This limit is thought to arise from the brain's capacity to fl..
Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging
Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensiti..
Neural Decoding of Visual Stimuli Varies with Fluctuations in Global Network Efficiency
Luca Cocchi, Zhengyi Yang, Andrew Zalesky, Johannes Stelzer, Luke J Hearne, Leonardo L Gollo, Jason B Mattingley
Functional magnetic resonance imaging (fMRI) studies have shown that neural activity fluctuates spontaneously between different st..
Accelerated Gray and White Matter Deterioration With Age in Schizophrenia
Vanessa L Cropley, Paul Klauser, Rhoshel K Lenroot, Jason Bruggemann, Suresh Sundram, Chad Bousman, Avril Pereira, Maria A Di Biase, Thomas W Weickert, Cynthia Shannon Weickert, Christos Pantelis, Andrew Zalesky
OBJECTIVE: Although brain changes in schizophrenia have been proposed to mirror those found with advancing age, the trajectory of ..
White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs
Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky
White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..
Connectome sensitivity or specificity: which is more important?
Andrew Zalesky, Alex Fornito, Luca Cocchi, Leonardo L Gollo, Martijn P van den Heuvel, Michael Breakspear
Connectomes with high sensitivity and high specificity are unattainable with current axonal fiber reconstruction methods, particul..
A hierarchy of timescales explains distinct effects of local inhibition of primary visxc ual cortex and frontal eye fields
Luca Cocchi, Martin V Sale, Leonardo L Gollo, Peter T Bell, Vinh T Nguyen, Andrew Zalesky, Michael Breakspear, Jason B Mattingley
Within the primate visual system, areas at lower levels of the cortical hierarchy process basic visual features, whereas those at ..
Hippocampal harms, protection and recovery following regular cannabis use
M Yuecel, V Lorenzetti, C Suo, A Zalesky, A Fornito, MJ Takagi, DI Lubman, N Solowij
Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for healt..
Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation
Martin V Sale, Jason B Mattingley, Andrew Zalesky, Luca Cocchi
The flexible integration of segregated neural processes is essential to healthy brain function. Advances in neuroimaging technique..
Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings
Andrew Zalesky, Christos Pantelis, Vanessa Cropley, Alex Fornito, Luca Cocchi, Harrison McAdams, Liv Clasen, Deanna Greenstein, Judith L Rapoport, Nitin Gogtay
IMPORTANCE: Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnorm..
Developmental Changes in Brain Network Hub Connectivity in Late Adolescence
Simon TE Baker, Dan I Lubman, Murat Yuecel, Nicholas B Allen, Sarah Whittle, Ben D Fulcher, Andrew Zalesky, Alex Fornito
The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is th..
Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics
Luca Cocchi, Martin V Sale, Anton Lord, Andrew Zalesky, Michael Breakspear, Jason B Mattingley
Normal brain function depends on a dynamic balance between local specialization and large-scale integration. It remains unclear, h..
A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS)
Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Andrew Zalesky, Masaaki Hori, Keigo Shimoji, Junichi Saito, Shinya Ito, Dominic B Dwyer, Issei Fukunaga, Keiko Morita, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
BACKGROUND: Evidence supports disruption in white matter (WM) connectivity in established schizophrenia, however, it is unclear wh..
Disruption of brain white matter microstructure in women with anorexia nervosa
Esther Via, Andrew Zalesky, Isabel Sanchez, Laura Forcano, Ben J Harrison, Jesus Pujol, Fernando Fernandez-Aranda, Jose Manuel Menchon, Carles Soriano-Mas, Narcis Cardoner, Alex Fornito
BACKGROUND: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its ..
Large-Scale Brain Network Dynamics Supporting Adolescent Cognitive Control
Dominic B Dwyer, Ben J Harrison, Murat Yuecel, Sarah Whittle, Andrew Zalesky, Christos Pantelis, Nicholas B Allen, Alex Fornito
Adolescence is a time when the ability to engage cognitive control is linked to crucial life outcomes. Despite a historical focus ..
Disruption of structure-function coupling in the schizophrenia connectome
Luca Cocchi, Ian H Harding, Anton Lord, Christos Pantelis, Murat Yucel, Andrew Zalesky
Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functi..