WHY VIRAL INFECTION LIMITS EFFECTIVENESS OF ANTI-ASTHMA DRUGS
Grant number: 1059665 | Funding period: 2014 - 2016
Chronic inflammatory lung diseases like asthma and smokers lung are treated with combinations of anti-inflammatory drugs. Powerful anti-inflammatory types of steroid drugs are used in more severe disease. Even these powerful drugs are sometimes not effective enough. Our work is developing an understanding of how inflammation limits the anti-inflammatory effects of steroids and we are devising ways to overcome this with new drugs. We aim to improve treatment of chronic inflammatory diseases, especially those affecting the lung.
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Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are commonly associated with respiratory syncytial virus (RS..
Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-beta 1
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BACKGROUND: We have previously shown that transforming growth factor-beta (TGF-beta) impairs glucocorticoid (GC) function in pulmo..