AN INVESTIGATION INTO THE MOLECULAR BASIS OF MAIT CELL RECOGNITION OF VITAMIN B BASED METABOLITES

Grant number: 1063587 | Funding period: 2014 - 2016

Completed

Abstract

Mucosal associated invariant T cells (MAIT cells) are an abundant T-cell population in humans, that is found mostly in the gastrointestinal mucosa. We have recently shown that MAIT cells can be activated by metabolites of vitamin B. This proposal will investigate how the MAIT cells "see" vitamin B metabolites. This research will pave the way for novel therapeutics that can modulate MAIT cell activity.

University of Melbourne Researchers