Using 'Omic and Digital Technologies Toward Better Fasciolosis Control

Chromatin accessibility landscape of a parasitic nematode during embryogenesis

Hanyu Lu, Tulio Campos, Sunita B Sumanam, Tao Wang, Yuanting Zheng, Robin B Gasser, Neil D Young

2026-12-01

Background: Chromatin accessibility is a fundamental determinant of genome regulation, enabling transcription factors and RNA poly..

Chromosome-scale nuclear genome and proteome of Anoplocephala perfoliata elucidate lineage-specific features of a ‘neglected’ equine tapeworm

ND Young, T Wang, CS Ang, D Lale, HP Fuehrer, SB Sumanam, PK Korhonen, BCH Chang, RB Gasser

2026-12-01

Background: Anoplocephala perfoliata is the most prevalent and pathogenic tapeworm (cestode) of horses worldwide, yet it remains m..

Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus

Y Shen, ND Young, J Song, BE Sleebs, BCH Chang, EF Lee, WD Fairlie, RB Gasser

2026-12-01

Background: Programmed cell death (or apoptosis) is a fundamental process in metazoans, extensively characterised in mammals and o..

Mitogenomic characterisation of non-native freshwater snails in Australia: Implications for biosecurity and trematode vector surveillance

T Sukee, SB Sumanam, ZY Chen, JE Hodgkinson, N Wiedemar, BL Webster, WF Ponder, BCH Chang, RB Gasser, AV Koehler, ND Young

2026-12-01

Freshwater snails play essential roles in the transmission of trematode parasites that affect humans, livestock and wildlife. Aust..

Rethinking Fasciola hepatica control under changing transmission risk: lessons from Australia and New Zealand

P Huynh, T Sukee, RM Athar Ali, A Koehler, ND Young, NED Calvani

2026-11-01

In many endemic livestock systems, Fasciola hepatica control is built around locally predictable transmission patterns that guide ..

Genome-wide population genomic analyses reveal extensive admixture and limited geographic structure in Australian Fasciola hepatica.

Mengwei Zheng, Tanapan Sukee, Aya C Taki, Jane E Hodgkinson, Steve Paterson, Terry W Spithill, Robin B Gasser, Neil D Young

2026-10-22

Fasciola hepatica is a globally important trematode parasite of livestock and humans, but its population structure in Australia re..

Intrinsic apoptosis in nematodes: Evolutionary plasticity and biotechnological opportunities

M Kaethner, ND Young, EF Lee, WD Fairlie, BE Sleebs, BCH Chang, RB Gasser

2026-09-01

Intrinsic apoptosis is a form of programmed cell death that underpins development, tissue homeostasis and stress responses across ..

High-resolution climate modelling of fasciolosis risk in Australia: A One Health early-warning framework

RM Athar Ali, MA Stevenson, L Tyrell, NED Calvani, T Beddoe, G Rawlin, T Spithill, ND Young, A Jabbar

2026-06-01

Fasciolosis, caused by the liver fluke Fasciola hepatica, is a climate-sensitive parasitic disease that threatens livestock health..

A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro

M Zheng, AC Taki, T Sukee, J Hodgkinson, TW Spithill, RB Gasser, ND Young

2026-04-01

Fasciola hepatica causes fasciolosis in livestock and humans worldwide, yet reliable tools to assess drug efficacy against the ear..