Temporal Strain Structure and Response to Interventions in a High Endemicity Region of Plasmodium Falciparum.

The dynamics of asymptomatic Plasmodium spp. infections following 10 years of malaria control interventions in Northern Sahelian Ghana.

Cecilia A Rios-Teran, Kathryn E Tiedje, Oscar Bangre, Samantha L Deed, Dionne C Argyropoulos, Kwadwo A Koram, Abraham R Oduro, Patrick O Ansah, Karen P Day

2026-04-13

Current interventions targeting malaria control in sub-Saharan Africa (SSA) are focused on Plasmodium falciparum, the most prevale..

Model reduction and analysis: A case study of a malaria control model

Maame Akua Korsah, Stuart T Johnston, Kathryn Tiedje, Karen Day, Camelia R Walker, Jennifer A Flegg

2026-04-01

Globally rising cases of malaria have prompted concentrated efforts to control malaria transmission, utilising various mathematica..

Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions

Kathryn E Tiedje, Qi Zhan, Shazia Ruybal-Pésantez, Gerry Tonkin-Hill, Qixin He, Mun Hua Tan, Dionne C Argyropoulos, Samantha Deed, Anita Ghansah, Oscar Bangre, Abraham R Oduro, Kwadwo A Koram, Mercedes Pascual, Karen P Day

2025-10-28

<jats:p> Here, we introduce a new endpoint ‘census population size’ to evaluate the epidemiology and control o..

Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions.

Kathryn E Tiedje, Qi Zhan, Shazia Ruybal-Pésantez, Gerry Tonkin-Hill, Qixin He, Mun Hua Tan, Dionne C Argyropoulos, Samantha Deed, Anita Ghansah, Oscar Bangre, Abraham R Oduro, Kwadwo A Koram, Mercedes Pascual, Karen P Day

2025-10-28

Here, we introduce a new endpoint 'census population size' to evaluate the epidemiology and control of Plasmodium falciparum infec..

Var genes, strain hyperdiversity, and malaria transmission dynamics

KP Day, MH Tan, Q He, S Ruybal-Pesántez, Q Zhan, KE Tiedje, M Pascual

2025-06-01

The microbiological paradigm for surveillance of diverse pathogens requires knowledge of the variation of the major surface antige..

A paradoxical population structure of var DBLα types in Africa

MH Tan, KE Tiedje, Q Feng, Q Zhan, M Pascual, H Shim, YB Chan, KP Day

2025-02-01

The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), central to host-parasite interacti..

Metagenomic complexity of high, seasonal transmission of Plasmodium spp. in asymptomatic carriers in Northern Sahelian Ghana

MH Tan, O Bangre, CA Rios-Teran, KE Tiedje, SL Deed, Q Zhan, F Rasyidi, M Pascual, PO Ansah, KP Day

2025-01-01

Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surp..

Hyper-diverse antigenic variation and resilience to transmission-reducing intervention in falciparum malaria

Qi Zhan, Qixin He, Kathryn E Tiedje, Karen P Day, Mercedes Pascual

2024-08-26

Intervention efforts against falciparum malaria in high-transmission regions remain challenging, with rapid resurgence typically f..

Mathematical Assessment of the Role of Intervention Programs for Malaria Control

MA Korsah, ST Johnston, KE Tiedje, KP Day, JA Flegg, CR Walker

2024-08-01

Malaria remains a global health problem despite the many attempts to control and eradicate it. There is an urgent need to understa..

Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum.

Mun Hua Tan, Heejung Shim, Yao-Ban Chan, Karen P Day

2023-01-09

The enormous diversity and complexity of var genes that diversify rapidly by recombination has led to the exclusion of assembly of..

Comparison of molecular surveillance methods to assess changes in the population genetics of Plasmodium falciparum in high transmission

A Ghansah, KE Tiedje, DC Argyropoulos, CO Onwona, SL Deed, F Labbé, AR Oduro, KA Koram, M Pascual, KP Day

2023-01-01

A major motivation for developing molecular methods for malaria surveillance is to measure the impact of control interventions on ..

Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections

F Labbé, Q He, Q Zhan, KE Tiedje, DC Argyropoulos, MH Tan, A Ghansah, KP Day, M Pascual

2023-01-01

At a time when effective tools for monitoring malaria control and eradication efforts are crucial, the increasing availability of ..

Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood stage infection throughout life

S Ruybal-Pesántez, KE Tiedje, S Pilosof, G Tonkin-Hill, Q He, TS Rask, L Amenga-Etego, AR Oduro, KA Koram, M Pascual, KP Day

2022-10-01

Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-endemic areas are at risk of infection ..

Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana

KE Tiedje, AR Oduro, O Bangre, L Amenga-Etego, SK Dadzie, MA Appawu, K Frempong, V Asoala, S Ruybal-Pésantez, CA Narh, SL Deed, DC Argyropoulos, A Ghansah, SA Agyei, S Segbaya, K Desewu, I Williams, JA Simpson, K Malm, M Pascual

2022-05-18

High-malaria burden countries in sub-Saharan Africa are shifting from malaria control towards elimination. Hence, there is need to..

An accurate method for identifying recent recombinants from unaligned sequences

Q Feng, KE Tiedje, S Ruybal-Pesantez, G Tonkin-Hill, MF Duffy, KP Day, H Shim, YB Chan

2022-04-01

Motivation: Recombination is a fundamental process in molecular evolution, and the identification of recombinant sequences is thus..

The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

DC Argyropoulos, S Ruybal-Pesántez, SL Deed, AR Oduro, SK Dadzie, MA Appawu, V Asoala, M Pascual, KA Koram, KP Day, KE Tiedje

2021-08-01

Here, we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparu..

Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission

Q He, S Pilosof, KE Tiedje, KP Day, M Pascual

2021-05-26

In high-transmission endemic regions, local populations of Plasmodium falciparum exhibit vast diversity of the var genes encoding ..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

G Tonkin-Hill, S Ruybal-Pesántez, KE Tiedje, V Rougeron, MF Duffy, S Zakeri, T Pumpaibool, P Harnyuttanakorn, OLH Branch, L Ruiz-Mesía, TS Rask, F Prugnolle, AT Papenfuss, YB Chan, KP Day

2021-02-25

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..

Evolution of antimalarial drug resistance markers in the reservoir of plasmodium falciparum infections in the upper east region of Ghana

CA Narh, A Ghansah, MF Duffy, S Ruybal-Pesántez, CO Onwona, AR Oduro, KA Koram, KP Day, KE Tiedje

2020-11-15

Background. The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high-tra..

Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum

S Pilosof, Q He, KE Tiedje, S Ruybal-Pesántez, KP Day, M Pascual

2019-06-01

In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantag..