Grant number: 105450 | Funding period: 2019 - 2025
Completed
G Pontillo, S Penna, F Arrigoni, B Bender, S Boesch, A Brunetti, F Cendes, S Chopra, LA Corben, A Deistung, MB Delatycki, S Diciotti, I Dogan, GF Egan, MC França, N Georgiou-Karistianis, SL Göricke, PG Henry, CR Hernandez-Castillo, D Hutter
2026-03-01
Background Friedreich ataxia (FRDA) is an inherited, progressive neurodegenerative disease. Interindividual heterogeneity in the r..
S Liu, I Agartz, P Allen, GP Amminger, OA Andreassen, P Bachman, I Baeza, H Baldwin, CF Bartholomeusz, S Borgwardt, S Catalano, X Chen, KIK Cho, S Choi, T Colibazzi, RE Cooper, CM Corcoran, VL Cropley, L de Haan, C de la Fuente-Sandoval
Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psyc..
M Kirschner, B Hodzic-Santor, L Kennedy, JY Hansen, M Antoniades, I Nenadić, T Kircher, A Krug, T Meller, U Dannlowski, D Grotegerd, K Flinkenflügel, S Meinert, T Borgers, J Goltermann, T Hahn, J Böhnlein, EJ Leehr, C Barkhau, A Fornito
2026-01-01
Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurode..
LKM Han, WB Bruin, JM Bas-Hoogendam, NA Groenewold, K Hilbert, AM Winkler, A Zugman, T Asami, JP Barber, F Benedetti, RJR Blair, J Böhnlein, P Brambilla, F Breuer, RL Buckner, R Bülow, ME Calkins, N Chechko, U Dannlowski, K Dohm
Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns pr..
A Lella, LA Antonucci, R Passiatore, L Bellantuono, P Selvaggi, T Popolizio, G Di Sciascio, A Saponaro, P Ricci, M Altamura, G Blasi, A Rampino, C Vriend, VD Calhoun, K Rootes-Murdy, AL Goldman, I Baeza, J Castro-Fornieles, G Sugranyes, E De la Serna
2025-11-01
Background: Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative ..
Wolfgang Omlor, Finn Rabe, Simon Fuchs, Werner Surbeck, Giacomo Cecere, Gao-Yang Huang, Stephanie Homan, Nils Kallen, Foivos Georgiadis, Tobias Spiller, Erich Seifritz, Thomas Weickert, Jason Bruggemann, Cynthia Weickert, Steven Potkin, Ryota Hashimoto, Kang Sim, Kelly Rootes-Murdy, Yann Quide, Josselin Houenou
2025-04-01
OBJECTIVE: The clinical diversity of schizophrenia is reflected by structural brain variability. It remains unclear how this varia..
JMM Bayer, LS van Velzen, E Pozzi, C Davey, LKM Han, SEEC Bauduin, J Bauer, F Benedetti, K Berger, LM Bonnekoh, K Brosch, R Bülow, B Couvy-Duchesne, KR Cullen, U Dannlowski, D Dima, K Dohm, JW Evans, CHY Fu, P Fuentes-Claramonte
2025-03-18
IMPORTANCE: Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation a..
Y Jiang, C Luo, J Wang, L Palaniyappan, X Chang, S Xiang, J Zhang, M Duan, H Huang, C Gaser, K Nemoto, K Miura, R Hashimoto, LT Westlye, G Richard, S Fernandez-Cabello, N Parker, OA Andreassen, T Kircher, I Nenadić
2024-12-01
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorde..
Eamonn Kennedy, Shashank Vadlamani, Hannah M Lindsey, Pui-Wa Lei, Mary Jo-Pugh, Paul M Thompson, David F Tate, Frank G Hillary, Emily L Dennis, Elisabeth A Wilde, null ENIGMA Clinical Endpoints Working Group
2024-10-16
Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. The..
K Rootes-Murdy, S Panta, R Kelly, J Romero, Y Quidé, MJ Cairns, C Loughland, VJ Carr, SV Catts, A Jablensky, MJ Green, F Henskens, D Kiltschewskij, PT Michie, B Mowry, C Pantelis, PE Rasser, WR Reay, U Schall, RJ Scott
2024-07-12
Structural neuroimaging studies have identified a combination of shared and disorder-specific patterns of gray matter (GM) deficit..
Eamonn Kennedy, Spencer W Liebel, Hannah M Lindsey, Shashank Vadlamani, Pui-Wa Lei, Maheen M Adamson, Martin Alda, Silvia Alonso-Lana, Tim J Anderson, Celso Arango, Robert F Asarnow, Mihai Avram, Rosa Ayesa-Arriola, Talin Babikian, Nerisa Banaj, Laura J Bird, Stefan Borgwardt, Amy Brodtmann, Katharina Brosch, Karen Caeyenberghs
2024-06-29
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studie..
Foivos Georgiadis, Sara Lariviere, David Glahn, L Elliot Hong, Peter Kochunov, Bryan Mowry, Carmel Loughland, Christos Pantelis, Frans A Henskens, Melissa J Green, Murray J Cairns, Patricia T Michie, Paul E Rasser, Stanley Catts, Paul Tooney, Rodney J Scott, Ulrich Schall, Vaughan Carr, Yann Quide, Axel Krug
2024-06-01
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether t..
S Si, A Bi, Z Yu, C See, S Kelly, S Ambrogi, C Arango, I Baeza, N Banaj, M Berk, J Castro-Fornieles, B Crespo-Facorro, JJ Crouse, CM Díaz-Caneja, AK Fett, A Fortea, S Frangou, BI Goldstein, IB Hickie, J Janssen
2024-02-01
Introduction: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but pr..
SS Haas, R Ge, I Agartz, GP Amminger, OA Andreassen, P Bachman, I Baeza, S Choi, T Colibazzi, VL Cropley, C De La Fuente-Sandoval, BH Ebdrup, A Fortea, P Fusar-Poli, BY Glenthøj, LB Glenthøj, KM Haut, RA Hayes, K Heekeren, CI Hooker
2024-01-03
Importance: The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A com..
Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A Andreassen, Tilo Kircher, Igor Nenadić
2023-10-12
Machine learning can be used to define subtypes of psychiatric conditions based on shared clinical and biological foundations, pre..
Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher RK Ching, Annabelle Harvey, Sandra Martin-Brevet, Guillaume Huguet, Martineau Jean-Louis, Elise Douard, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Anne M Maillard, Borja Rodriguez-Herreros, Aurélie Pain, null 16p11.2 European Consortium, Simons Searchlight Consortium, Leila Kushan, Dmitry Isaev, Kathryn Alpert, Anjani Ragothaman
2023-09-01
OBJECTIVE: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychia..
Eamonn Kennedy, Shashank Vadlamani, Hannah M Lindsey, Pui-Wa Lei, Mary Jo-Pugh, Maheen Adamson, Martin Alda, Silvia Alonso-Lana, Sonia Ambrogi, Tim J Anderson, Celso Arango, Robert F Asarnow, Mihai Avram, Rosa Ayesa-Arriola, Talin Babikian, Nerisa Banaj, Laura J Bird, Stefan Borgwardt, Amy Brodtmann, Katharina Brosch
2023-04-07
Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample sizes, st..
D Schijven, MC Postema, M Fukunaga, J Matsumoto, K Miura, SMC de Zwarte, NEM van Haren, W Cahn, HE Hulshoff Pol, RS Kahn, R Ayesa-Arriola, VOG de la Foz, D Tordesillas-Gutierrez, J Vázquez-Bourgon, B Crespo-Facorro, D Alnæs, A Dahl, LT Westlye, I Agartz, OA Andreassen
2023-04-04
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studie..
C Constantinides, LKM Han, C Alloza, LA Antonucci, C Arango, R Ayesa-Arriola, N Banaj, A Bertolino, S Borgwardt, J Bruggemann, J Bustillo, O Bykhovski, V Calhoun, V Carr, S Catts, YC Chung, B Crespo-Facorro, CM Díaz-Caneja, G Donohoe, SD Plessis
2023-03-01
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and prema..
C Barth, S Kelly, S Nerland, N Jahanshad, C Alloza, S Ambrogi, OA Andreassen, D Andreou, C Arango, I Baeza, N Banaj, CE Bearden, M Berk, H Bohman, J Castro-Fornieles, Y Chye, B Crespo-Facorro, E de la Serna, CM Díaz-Caneja, TP Gurholt
Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years)...
Z Cao, RB Cupertino, J Ottino-Gonzalez, A Murphy, D Pancholi, A Juliano, B Chaarani, M Albaugh, D Yuan, N Schwab, J Stafford, AE Goudriaan, K Hutchison, CSR Li, M Luijten, M Groefsema, R Momenan, L Schmaal, R Sinha, RJ van Holst
2023-02-01
The neurobiological bases of the association between development and psychopathology remain poorly understood. Here, we identify a..
BY Park, V Kebets, S Larivière, MD Hettwer, C Paquola, D van Rooij, J Buitelaar, B Franke, M Hoogman, L Schmaal, DJ Veltman, OA van den Heuvel, DJ Stein, OA Andreassen, CRK Ching, JA Turner, TGM van Erp, AC Evans, A Dagher, SI Thomopoulos
2022-12-01
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar br..
JMM Bayer, PM Thompson, CRK Ching, M Liu, A Chen, AC Panzenhagen, N Jahanshad, A Marquand, L Schmaal, PG Sämann
2022-10-31
Site differences, or systematic differences in feature distributions across multiple data-acquisition sites, are a known source of..
Y Patel, J Shin, C Abé, I Agartz, C Alloza, D Alnæs, S Ambrogi, LA Antonucci, C Arango, V Arolt, G Auzias, R Ayesa-Arriola, N Banaj, T Banaschewski, C Bandeira, Z Başgöze, RB Cupertino, CHD Bau, J Bauer, S Baumeister
2022-08-15
Background: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental orig..
EJ Cheon, CE Bearden, D Sun, CRK Ching, OA Andreassen, L Schmaal, DJ Veltman, SI Thomopoulos, P Kochunov, N Jahanshad, PM Thompson, JA Turner, TGM van Erp
2022-05-01
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), a..
C Abé, CRK Ching, B Liberg, AV Lebedev, I Agartz, TN Akudjedu, M Alda, D Alnæs, S Alonso-Lana, F Benedetti, M Berk, E Bøen, CDM Bonnin, F Breuer, K Brosch, RM Brouwer, EJ Canales-Rodríguez, DM Cannon, Y Chye, A Dahl
2022-03-15
Background: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whethe..
P Kochunov, LE Hong, EL Dennis, RA Morey, DF Tate, EA Wilde, M Logue, S Kelly, G Donohoe, P Favre, J Houenou, CRK Ching, L Holleran, OA Andreassen, LS van Velzen, L Schmaal, JE Villalón-Reina, CE Bearden, F Piras, G Spalletta
2022-01-01
The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and d..
SMC de Zwarte, RM Brouwer, I Agartz, M Alda, S Alonso-Lana, CE Bearden, A Bertolino, A Bonvino, E Bramon, EEL Buimer, W Cahn, EJ Canales-Rodríguez, DM Cannon, TD Cannon, X Caseras, J Castro-Fornieles, Q Chen, Y Chung, E De la Serna, C del Mar Bonnin
First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cogniti..
PM Thompson, N Jahanshad, L Schmaal, JA Turner, AM Winkler, SI Thomopoulos, GF Egan, P Kochunov
This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Met..
Z Cao, J Ottino-Gonzalez, RB Cupertino, N Schwab, C Hoke, O Catherine, J Cousijn, A Dagher, JJ Foxe, AE Goudriaan, R Hester, K Hutchison, CSR Li, ED London, V Lorenzetti, M Luijten, R Martin-Santos, R Momenan, MP Paulus, L Schmaal
2021-09-01
Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age an..
NV Radonjić, JL Hess, P Rovira, O Andreassen, JK Buitelaar, CRK Ching, B Franke, M Hoogman, N Jahanshad, C McDonald, L Schmaal, SM Sisodiya, DJ Stein, OA van den Heuvel, TGM van Erp, D van Rooij, DJ Veltman, P Thompson, SV Faraone
2021-06-01
Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we ..
J Radua, E Vieta, R Shinohara, P Kochunov, Y Quidé, MJ Green, CS Weickert, T Weickert, J Bruggemann, T Kircher, I Nenadić, MJ Cairns, M Seal, U Schall, F Henskens, JM Fullerton, B Mowry, C Pantelis, R Lenroot, V Cropley
2020-09-01
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..
SN Hatton, KH Huynh, L Bonilha, E Abela, S Alhusaini, A Altmann, MKM Alvim, AR Balachandra, E Bartolini, B Bender, N Bernasconi, A Bernasconi, B Bernhardt, N Bargallo, B Caldairou, ME Caligiuri, SJA Carr, GL Cavalleri, F Cendes, L Concha
2020-08-01
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitat..