Hitting Bacteria With a Bam: Lectin-Like Antimicrobials as New Antibiotics

L-type pyocins inhibit the BAM complex to kill without cell entry.

Fabian Munder, Matthew D Johnson, Imogen Samuels, Laura McCaughey, Oleksii Zdorevskyi, Chunxiao Wang, Ashleigh Kropp, Lauren Zavan, Erin P Price, Derek S Sarovich, Swati Varshney, Christopher A McDevitt, Hari Venugopal, Vivek Sharma, Matthew T Doyle, Francesca Short, Debnath Ghosal, James PR Connolly, Gavin J Knott, Rhys Grinter

2026-07-02

Many antibiotics are ineffective against the Gram-negative pathogen Pseudomonas aeruginosa because of intrinsic defence mechanisms..

Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins

DR Fox, K Asadollahi, I Samuels, BA Spicer, A Kropp, CJ Lupton, K Lim, C Wang, H Venugopal, M Dramicanin, GJ Knott, R Grinter

2025-12-01

Iron is an essential nutrient for most bacteria and is often growth-limiting during infection, due to the host sequestering free i..

Code to complex: AI-driven de novo binder design

DR Fox, C Taveneau, J Clement, R Grinter, GJ Knott

2025-10-02

The application of artificial intelligence to structural biology has transformed protein design from a conceptual challenge into a..

High-affinity PQQ import is widespread in Gram-negative bacteria

F Munder, M Voutsinos, K Hantke, H Venugopal, R Grinter

2025-05-01

Pyrroloquinoline quinone (PQQ) is a soluble redox cofactor used by diverse bacteria. Many Gram-negative bacteria that encode PQQ-d..