Unravelling Efficient Nucleic Acid Delivery Using Multilayer Nanoparticles

Introduction to “Endocytosis and cellular delivery”

A Kros, G Such, VM Rotello

2026-01-01

Alexander Kros, Georgina Such, and Vincent Rotello introduce the RSC Pharmaceutics and RSC Chemical Biology themed collection on E..

Radical ring-opening polymerization-induced self-assembly for the synthesis of degradable particles incorporating ethyl lipoate

F Yang, JF White, Y Wang, Y Gao, D Yuen, APR Johnston, A Postma, LD Blackman, GK Such

2026-01-01

Polymeric nanoparticles are widely used in biomedical applications due to their ability to protect cargo, enhance bioavailability ..

Monitoring structural change and drug release of responsive nanoparticles using polarity-sensitive fluorophores

Y Gao, PW McDonald, C Ritchie, GK Such

2025-12-28

Stimuli-responsive polymeric nanoparticles hold significant promise for enhancing the delivery of therapeutic agents, particularly..

Gene Delivery with Dual pH- and GSH-Responsive Lipoamide Polymers from Controlled Polymerization of Protected Lipoic Acid

F Yang, C Zhang, SA Smith, B Rossi Herling, D Yuen, Y Wang, U Nayanathara, Y Gao, APR Johnston, GK Such

2025-06-11

Gene delivery has great therapeutic potential, but there remain significant barriers for the effective use of this technology, inc..

Unravelling the endosomal escape of pH-responsive nanoparticles using the split luciferase endosomal escape quantification assay

U Nayanathara, F Yang, C Zhang, Y Wang, B Rossi Herling, SA Smith, MA Beach, APR Johnston, GK Such

2025-01-20

Endosomal escape is a major bottleneck for efficient intracellular delivery of therapeutic cargoes, particularly for macromolecula..

Cholic-Acid Derived, Guanidine-Functionalized Polymers as Broad-Spectrum Antimicrobial Agents

Y Xiong, U Nayanathara, X Lai, X Huang, C Zhang, D Yuen, P Sangwan, HH Shen, APR Johnston, BW Muir, GK Such

2024-12-10

In this study, we report the design of a new guanylated, cholic-acid-based monomer (GM) to combat antimicrobial resistance. The mi..

Facile construction of polyoxometalate-polymer hybrid nanoparticles with pH/redox dual-responsiveness

Y Gao, F Yang, Y Wang, APR Johnston, RN Duffin, PC Andrews, C Ritchie, GK Such

2024-11-15

Responsive nanomaterials have emerged as promising candidates for advanced drug delivery systems (DDSs), offering the potential to..