Exploiting the Unique Functions of MAIT Cells to Drive the Rational Design of New Vaccines and Immunotherapies

Specific targeting of MR1-antigen complexes using nanobodies.

Hisham S Hussain, Samuel J Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis P Gonzalez, Jeffrey YW Mak, David P Fairlie, James McCluskey, Alexandra J Corbett, Adam P Uldrich, Jamie Rossjohn, Dale I Godfrey, Hui-Fern Koay, Nicholas A Gherardin

2026-09-25

T cell receptor mimic (TCRm) antibodies that bind peptide-human leukocyte antigen complexes have great therapeutic potential. Majo..

NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells

AJ Sedgwick, MAAK Khan, N Ghazanfari, T Mantamadiotis, AJ Corbett, JP Vivian, AD Barrow

2026-07-01

Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinfl..

Utility and Limitations of the Methyl Diaminobenzene-BODIPY Fluorescent Biosensor for Detecting Methylglyoxal in Cells

R Ponvattanaporn, JP Le, Z Li, RJD Rivero, JYW Mak, DP Fairlie, HEG McWilliam, A Hachani, AJ Corbett, T Patton

2026-06-09

Methylglyoxal (MG) is a small and highly reactive byproduct of multiple metabolic reactions. In mammalian cells, MG serves importa..

The NKp44-1 Isoform Is an Activating Receptor for PDGF-DD Expressed on Natural Killer Cells

AJ Sedgwick, MAAK Khan, STD Pham, MA Edeling, AJ Corbett, JP Vivian, Y Palarasah, AD Barrow

2026-04-01

Background/Objectives: Natural killer (NK) cells are key innate lymphoid cells that restrict tumour progression by secreting proin..

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

JYW Mak, HN Hoang, W Awad, XY Lim, DD Laurie, RJD Rivero, J McCluskey, AJ Corbett, J Rossjohn, DP Fairlie

2026-01-01

Mucosal-associated invariant T cells (MAIT cells) are innate-like immune cells (T lymphocytes) that protect against bacterial infe..

Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity

EM Eddy, T Patton, AD Barrow, AJ Corbett

2026-01-01

Glioblastomas (GBM) are an aggressive form of brain cancer with no curative treatment options. While T cell therapies have demonst..